Psyllium Interactions

Psyllium is a soluble fiber that forms a viscous gel in the gut, which can trap warfarin and slow or reduce its absorption when taken at the same time. Significant changes in fiber intake may also alter gut flora vitamin K production, indirectly destabilizing INR.

Psyllium forms a viscous gel that can physically trap metformin in the gut and slow its absorption, potentially reducing peak plasma levels and blood-glucose control when both are taken simultaneously. Soluble fiber can also independently lower postprandial glucose, which may compound metformin's hypoglycemic effect.