Cholesterol Support

Red yeast rice contains monacolin K, the same active compound as the prescription statin lovastatin. Trial evidence shows ~20-30% LDL reduction at 1200-2400 mg/day. Treat with the same precautions as a statin: pair with CoQ10, monitor liver function, watch for muscle symptoms, avoid in pregnancy. Product quality varies enormously — choose a third-party-tested brand.^{[1, 2, 3]}

Bergamot polyphenols reduce LDL through a non-statin mechanism. Trial evidence shows 15-30% LDL reduction at standardized doses over 6-12 weeks. Particularly useful for statin-intolerant adults or as add-on to a statin for additional LDL reduction.^{[4, 5, 6]}

Plant sterols and stanols block intestinal absorption of dietary and biliary cholesterol. Trial evidence consistently shows 8-10% LDL reduction at 2 g/day. Often added to margarines and yogurts (Benecol, Take Control); supplemental capsules also work.^{[7, 8]}

Red yeast rice and statins both deplete endogenous CoQ10 production via the same mechanism. CoQ10 supplementation prevents this depletion and may reduce statin-related muscle symptoms. Mandatory pairing whenever using red yeast rice.^{[9, 10]}

Niacin raises HDL and lowers LDL. The AIM-HIGH trial showed no additional cardiovascular benefit over statins. Useful as a third-line option for adults with low HDL and high triglycerides. Inositol hexanicotinate causes less flushing than immediate-release niacin but the data is weaker. Discuss with your doctor — niacin has real drug interactions and hepatic effects.^{[11, 12]}