Hesperidin methyl chalcone

PhytochemicalFlavonoidBest with a meal

What is it

Hesperidin methyl chalcone (HMC) is a semi-synthetic derivative of the citrus flavonoid hesperidin, modified to improve solubility. It is used primarily in European phlebotonic products for chronic venous insufficiency and hemorrhoids.

Evidence for 2 uses

AI-assisted evidence assessment — talk to your doctor before relying on any single supplement.

Chronic venous insufficiency (combination products)

Good Evidence

Multiple European RCTs of butcher's broom + HMC + vitamin C combinations show modest symptom improvements vs. placebo.

Hemorrhoid symptoms

Limited Evidence

Some clinical evidence for short-term symptom relief in combination products.

How it works

HMC has venoconstrictive, anti-edema, and anti-inflammatory effects on the venous endothelium. It is a common component of combination products with butcher's broom and ascorbic acid (e.g., Cyclo 3 Fort), where it contributes to symptom relief in chronic venous insufficiency. Trials of these combinations show modest reductions in leg heaviness, pain, and swelling.

Dosage

No RDA. Combination products dose 75-150 mg of HMC per tablet, taken 1-3 times daily.

When and how to take it

Typically taken with meals; effects on venous symptoms develop over 2-4 weeks.

1 commercial form

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Combination tablets

Common European product.

Often with butcher's broom and vitamin C.

Safety

Well tolerated in long-term European post-marketing surveillance. Mild GI upset is the most common adverse effect.

Who should be cautious

Pregnancy: limited data for the synthetic derivative; combination products are sometimes used in third trimester for hemorrhoids in Europe but not without medical guidance. Lactation: insufficient data.

Interactions

No significant pharmacological interactions reported at typical doses.

Frequently asked questions

Is HMC the same as hesperidin?⌄

No. HMC is a methylated chalcone derivative with different solubility and pharmacology.

How long until I see effects?⌄

Usually 2-4 weeks of consistent daily use for venous symptoms.

References

Hesperidin methyl chalcone on NIH DSLD (US supplement label database) — NIH Dietary Supplement Label Database link

Research on Hesperidin methyl chalcone (PubMed search) — PubMed link

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Evidence-based·How we grade evidence

Disclaimer: These statements have not been evaluated by the FDA. This page is educational, not a substitute for personalized medical advice. Evidence grades are AI-assisted assessments — talk to your doctor before starting any new supplement, especially if you’re pregnant, breastfeeding, on medications, or managing a chronic condition.