Dimethyl chrysin

PhytochemicalFlavonoidBest in the morning

What is it

Dimethyl chrysin (5,7-dimethoxyflavone) is a methylated form of the flavone chrysin, found in plants including Kaempferia parviflora (black ginger). It is marketed in some supplements for testosterone and exercise support.

Evidence for 1 use

AI-assisted evidence assessment — talk to your doctor before relying on any single supplement.

Hormonal and exercise effects (as part of black ginger extracts)

Limited Evidence

Small trials of black ginger extracts containing dimethyl chrysin suggest modest improvements in exercise performance and erectile function; isolated dimethyl chrysin has not been well studied in humans.

How it works

5,7-Dimethoxyflavone has greater oral bioavailability than the parent flavone chrysin due to methylation. Preclinical work suggests aromatase inhibition (the enzyme converting testosterone to estrogen) and phosphodiesterase inhibition. Human evidence for testosterone effects is limited and largely inferred from Kaempferia parviflora extracts.

Dosage

No standardized dose. Black ginger extracts containing this compound are typically dosed at 90-180 mg of total extract per day.

When and how to take it

Often taken in the morning or before exercise. May be taken with or without food.

1 commercial form

Compare the main delivery options and what they’re best suited for.

Black ginger extract (containing 5,7-dimethoxyflavone)

Standardized extract form most commonly available.

Improved over chrysin by methylation; better absorption with fat-containing meals

Safety

Short-term safety reasonable based on Kaempferia trials. Long-term data are limited. Headache and stomach upset have been reported.

Who should be cautious

Avoid in pregnancy, breastfeeding, hormone-sensitive conditions, and in children. Caution alongside PDE5 inhibitors for erectile dysfunction.

Interactions

May inhibit cytochrome P450 enzymes in vitro; clinical relevance is uncertain. Caution with medications metabolized by CYP3A4.

Food sources

Black ginger (Kaempferia parviflora)

Amount
variable
%DV
—

Frequently asked questions

Is dimethyl chrysin a testosterone booster?⌄

Some preclinical work suggests aromatase inhibition. Human evidence for testosterone effects is limited and not conclusive.

Is it the same as regular chrysin?⌄

It is a methylated form with better oral absorption than chrysin, which itself has very poor bioavailability.

References

Dimethyl chrysin on NIH DSLD (US supplement label database) — NIH Dietary Supplement Label Database link

Research on Dimethyl chrysin (PubMed search) — PubMed link

Track Dimethyl chrysin with Pilora

Set up dose reminders, check interactions, and join the community in the Pilora iPhone app.

Coming to App Store
Evidence-based·How we grade evidence

Disclaimer: These statements have not been evaluated by the FDA. This page is educational, not a substitute for personalized medical advice. Evidence grades are AI-assisted assessments — talk to your doctor before starting any new supplement, especially if you’re pregnant, breastfeeding, on medications, or managing a chronic condition.