Didymin

PhytochemicalFlavonoidBest with a meal

What is it

Didymin (isosakuranetin-7-O-rutinoside) is a flavonoid glycoside found in citrus fruits, particularly in the peel and pulp of oranges, mandarins, and tangerines.

Evidence for 1 use

AI-assisted evidence assessment — talk to your doctor before relying on any single supplement.

Preclinical antioxidant / anti-inflammatory

Mixed Evidence

Preclinical activity has been described but no human clinical evidence supports specific health claims for didymin as an isolated supplement.

How it works

Didymin is a polyphenolic flavonoid that has been investigated in preclinical studies for antioxidant, anti-inflammatory, and antineoplastic activity. Cell and animal research has explored effects on neuroblastoma and other cancer cell lines, as well as anti-inflammatory effects in models of colitis and lung injury. Human clinical evidence for isolated didymin is essentially absent; what is known about citrus flavonoid health effects in humans comes from broader bioflavonoid mixtures.

Dosage

No established dose. Found at small amounts in citrus fruit and as a component of some citrus flavonoid supplements.

When and how to take it

Time of day is not established. Take with food.

1 commercial form

Compare the main delivery options and what they’re best suited for.

Component of citrus flavonoid blends

Rarely sold standalone; appears in citrus bioflavonoid complex products.

Limited PK data; expected to share characteristics of other flavonoid glycosides.

Safety

As a citrus flavonoid consumed in food amounts, considered safe. Concentrated isolated didymin supplements are uncommon and lack human safety data.

Who should be cautious

Limited human data; concentrated supplements should be used cautiously, especially in pregnancy and breastfeeding.

Interactions

Insufficient data on drug interactions for isolated didymin. Citrus flavonoids in general have minimal recognized interactions at dietary doses.

Food sources

Oranges, mandarins, tangerines

Amount
Small amounts naturally present
%DV
—

Frequently asked questions

Should I take a didymin supplement?⌄

Human evidence is essentially absent. Eating whole citrus fruit gives you a broader mix of flavonoids and is probably more beneficial.

References

Didymin on Wikidata — Wikidata link

Didymin (PubChem CID 477828) — PubChem link

Didymin on NIH DSLD (US supplement label database) — NIH Dietary Supplement Label Database link

Research on Didymin (PubMed search) — PubMed link

Track Didymin with Pilora

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Evidence-based·How we grade evidence

Disclaimer: These statements have not been evaluated by the FDA. This page is educational, not a substitute for personalized medical advice. Evidence grades are AI-assisted assessments — talk to your doctor before starting any new supplement, especially if you’re pregnant, breastfeeding, on medications, or managing a chronic condition.