Decursin

PhytochemicalCoumarin

What is it

Decursin is a pyranocoumarin compound found in the root of Angelica gigas (Korean angelica). It is studied for potential anti-cancer and neuroprotective activity in preclinical settings.

Evidence for 1 use

AI-assisted evidence assessment — talk to your doctor before relying on any single supplement.

Any clinical condition

Mixed Evidence

Activity has been seen in preclinical models. No controlled human trials have established clinical benefit.

How it works

In cell and animal models, decursin and its isomer decursinol angelate have shown effects on androgen receptor signaling, induction of apoptosis in cancer cells, and possible neuroprotective effects through reduction of oxidative stress. Following oral intake, decursin is rapidly hydrolyzed in plasma to decursinol, which is the predominant circulating form. The pharmacology of decursin in humans is still being characterized and few controlled trials exist.

Dosage

There is no established human dose for purified decursin. Standardized Angelica gigas root extracts in research studies have used hundreds of milligrams per day, but consumer products vary widely and dosing is not evidence-based.

When and how to take it

No evidence-based timing recommendation exists.

1 commercial form

Compare the main delivery options and what they’re best suited for.

Angelica gigas root extract

Primary natural source used in supplements.

Decursin is rapidly converted to decursinol in plasma.

Safety

Human safety data are limited. Animal studies suggest acceptable acute tolerability, but long-term human safety has not been formally evaluated.

Who should be cautious

Avoid during pregnancy and breastfeeding due to lack of safety data. Men with hormone-sensitive conditions (such as prostate cancer) should not self-treat and should consult a clinician.

Interactions

Theoretical interactions with cytochrome P450-metabolized medications and with androgen-related therapies. Specific data are sparse. People on prescription medications should discuss with a clinician.

Frequently asked questions

Is decursin the same as Angelica sinensis (dong quai)?⌄

No. Decursin comes from Angelica gigas (Korean angelica). Angelica sinensis (dong quai) is a different species used in Traditional Chinese Medicine.

Does decursin treat cancer?⌄

No. Preclinical activity has not translated to demonstrated human cancer treatment.

References

Decursin on Wikidata — Wikidata link

Decursin (ChEBI:4353) — ChEBI link

Decursin (PubChem CID 442126) — PubChem link

Decursin on NIH DSLD (US supplement label database) — NIH Dietary Supplement Label Database link

Research on Decursin (PubMed search) — PubMed link

Track Decursin with Pilora

Set up dose reminders, check interactions, and join the community in the Pilora iPhone app.

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Evidence-based·How we grade evidence

Disclaimer: These statements have not been evaluated by the FDA. This page is educational, not a substitute for personalized medical advice. Evidence grades are AI-assisted assessments — talk to your doctor before starting any new supplement, especially if you’re pregnant, breastfeeding, on medications, or managing a chronic condition.