Brutieridin

PhytochemicalFlavonoid glycosideBest with a meal

What is it

Brutieridin is a hesperetin-derived flavonoid glycoside found in bergamot (Citrus bergamia) along with related compound melitidin. They are key bioactives in standardized bergamot extracts.

Evidence for 1 use

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Lipid lowering (via bergamot extracts)

Good Evidence

Trials of standardized bergamot polyphenolic fractions show reductions in LDL-C and triglycerides. Brutieridin is considered a key contributor mechanistically.

How it works

Brutieridin contains a 3-hydroxy-3-methylglutaryl (HMG) moiety similar in structure to that of natural statins, leading to in vitro inhibition of HMG-CoA reductase, a key enzyme in cholesterol biosynthesis. This is the proposed mechanism for the lipid-lowering effects observed with bergamot extracts. Clinical studies use bergamot polyphenolic fractions (BPF) standardized to total flavonoids including brutieridin and melitidin, with measurable effects on lipid profile.

Dosage

There is no RDA. Bergamot extracts are usually dosed at 500-1500 mg/day standardized to total flavonoids; pure brutieridin is not separately dosed. DSLD does not provide a median dose for this entry.

When and how to take it

Take with food. Daily use over 4-12 weeks is needed to assess lipid changes.

1 commercial form

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Bergamot polyphenolic fraction (BPF)

Look for total flavonoid content and identification of brutieridin and melitidin.

Flavonoid glycosides; standardization varies by manufacturer.

Safety

Bergamot extracts have a generally good short-to-medium-term safety profile in trials. Mild GI symptoms are the most common side effect.

Who should be cautious

Caution if already on lipid-lowering therapy; coordinate with a clinician. Pregnancy and breastfeeding: insufficient data for high-dose extracts.

Interactions

Possible additive lipid-lowering effects with statins. Bergamot juice (not extracts) contains furanocoumarins that can inhibit CYP3A4; standardized extracts typically minimize this risk.

Food sources

Bergamot juice/peel

Amount
varies
%DV
—

Frequently asked questions

Is brutieridin a natural statin?⌄

It contains a statin-like HMG side chain and can inhibit HMG-CoA reductase in vitro. The clinical effect of bergamot extracts is more modest than prescription statins.

Can I take bergamot extract with my statin?⌄

Coordinate with your clinician. Combined use is studied, but additive lipid effects warrant monitoring.

References

Brutieridin on Wikidata — Wikidata link

Brutieridin on NIH DSLD (US supplement label database) — NIH Dietary Supplement Label Database link

Research on Brutieridin (PubMed search) — PubMed link

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Evidence-based·How we grade evidence

Disclaimer: These statements have not been evaluated by the FDA. This page is educational, not a substitute for personalized medical advice. Evidence grades are AI-assisted assessments — talk to your doctor before starting any new supplement, especially if you’re pregnant, breastfeeding, on medications, or managing a chronic condition.