Astragalin

PhytochemicalFlavonoidBest with a meal

What is it

Astragalin (kaempferol 3-glucoside) is a flavonoid glycoside found in many plants, including persimmon leaves, Cuscuta chinensis, Phytolacca americana, and Filipendula species. It is a common dietary flavonoid with antioxidant activity.

Evidence for 1 use

AI-assisted evidence assessment — talk to your doctor before relying on any single supplement.

Antioxidant and anti-inflammatory (general)

Mixed Evidence

In vitro and animal studies suggest activity; direct human evidence specifically for astragalin is absent.

How it works

After ingestion, astragalin is partially hydrolyzed by gut microbiota to release free kaempferol, which is then absorbed and metabolized. Both compounds show antioxidant, anti-inflammatory, and weak phytoestrogenic activity in laboratory studies. Animal studies suggest hepatoprotective, anti-diabetic, and anti-asthmatic effects. Direct human clinical evidence specifically for astragalin is essentially absent.

Dosage

No standardized human dose. Most evidence is from animal studies and from kaempferol research in general.

When and how to take it

Take with food for typical flavonoid absorption.

1 commercial form

Compare the main delivery options and what they’re best suited for.

Plant extracts containing astragalin

Component of various plant extracts.

Hydrolyzed to kaempferol by gut bacteria.

Safety

Limited specific human safety data on purified astragalin. Common dietary intake from foods is well tolerated.

Who should be cautious

Limited data for pregnancy and breastfeeding at supplement doses; dietary intake is fine.

Interactions

Possible interactions with CYP450-metabolized drugs (theoretical). May potentiate other antioxidants.

Food sources

Persimmon leaves, various vegetables

Amount
varied
%DV
—

Frequently asked questions

Is astragalin the same as astragalus?⌄

No. Astragalin is a single flavonoid; astragalus is an entire plant genus used in herbal medicine (though astragalin was originally identified in some Astragalus species).

Should I supplement astragalin?⌄

There is no good clinical evidence to recommend purified astragalin supplementation.

References

Astragalin on Wikidata — Wikidata link

Astragalin (ChEBI:30200) — ChEBI link

Astragalin (PubChem CID 5282102) — PubChem link

Astragalin on NIH DSLD (US supplement label database) — NIH Dietary Supplement Label Database link

Research on Astragalin (PubMed search) — PubMed link

Track Astragalin with Pilora

Set up dose reminders, check interactions, and join the community in the Pilora iPhone app.

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Evidence-based·How we grade evidence

Disclaimer: These statements have not been evaluated by the FDA. This page is educational, not a substitute for personalized medical advice. Evidence grades are AI-assisted assessments — talk to your doctor before starting any new supplement, especially if you’re pregnant, breastfeeding, on medications, or managing a chronic condition.