Alantolactone

PhytochemicalSesquiterpene lactone

What is it

Alantolactone is a sesquiterpene lactone found in elecampane (Inula helenium) and several related Inula species. It is the main bitter compound of the plant and has been studied for antiparasitic and anti-inflammatory activity.

Evidence for 1 use

AI-assisted evidence assessment — talk to your doctor before relying on any single supplement.

Intestinal parasites (historical)

Limited Evidence

Used historically for roundworm. Modern antiparasitic medications are far more effective and safer.

How it works

Alantolactone and its isomer isoalantolactone interact with multiple cellular pathways in laboratory studies, including NF-kB signaling, STAT3, and induction of apoptosis. Historically, alantolactone has been used in Europe as a treatment for intestinal parasites (particularly roundworm). The compound is reactive with thiol groups and can sensitize the skin or irritate mucous membranes. Modern controlled human trials are limited.

Dosage

There is no established modern supplemental dose. Historical antiparasitic use involved short-term, supervised treatment. Standardized extracts vary by manufacturer.

When and how to take it

No evidence-based timing recommendation. Traditional doses were taken short-term under supervision.

2 commercial forms

Compare the main delivery options and what they’re best suited for.

Elecampane root extract

Traditional preparation; constituent content variable.

Natural source containing alantolactone.

Isolated alantolactone

Used primarily in laboratory studies.

Research-grade material.

Safety

Alantolactone can cause contact dermatitis and skin sensitization. Oral use in significant amounts can cause GI symptoms (vomiting, diarrhea, cramping). Long-term safety has not been formally established.

Who should be cautious

Avoid during pregnancy and breastfeeding due to lack of safety data and historical association with uterine stimulation. People with known sensitivity to Compositae/Asteraceae plants (ragweed, chamomile, echinacea) should be cautious.

Interactions

Theoretical interactions with cytochrome P450 enzymes and with antiplatelet drugs based on preclinical findings. Specific clinical interaction data are sparse.

Frequently asked questions

Is elecampane safe to take?⌄

Short-term traditional use was generally tolerated, but alantolactone causes skin and GI irritation in many people. Modern medications offer safer alternatives for the same purposes.

Can alantolactone treat parasites?⌄

It was used historically, but modern antiparasitic drugs are much more reliable and have a better safety profile. Talk to a clinician if you suspect a parasitic infection.

References

Alantolactone on Wikidata — Wikidata link

Alantolactone (ChEBI:2540) — ChEBI link

Alantolactone (PubChem CID 72724) — PubChem link

Alantolactone on NIH DSLD (US supplement label database) — NIH Dietary Supplement Label Database link

Research on Alantolactone (PubMed search) — PubMed link

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Evidence-based·How we grade evidence

Disclaimer: These statements have not been evaluated by the FDA. This page is educational, not a substitute for personalized medical advice. Evidence grades are AI-assisted assessments — talk to your doctor before starting any new supplement, especially if you’re pregnant, breastfeeding, on medications, or managing a chronic condition.