Evidence-based·Last reviewed May 30, 2026·How we grade evidence

Chamomile

BotanicalApigeninBest before bedBest taken away from food

Useful mainly for adults with mild-to-moderate generalized anxiety.

Quick decision guide

May help most

adults with mild-to-moderate generalized anxiety

Common dosing range

500 mg standardized extract (1.2% apigenin) three times daily

When to expect effects

Weeks (2–4) for anxiety

Watch out for

allergic reactions in people sensitive to ragweed and related Asteraceae plants

What is it

Chamomile refers to two related flowering plants in the daisy family: German chamomile (Matricaria chamomilla) and Roman chamomile (Chamaemelum nobile). German chamomile is more commonly used medicinally. The dried flowers have been used as a mild sedative, anxiolytic, and digestive aid for over 4,000 years.

Is it worth it for you?

Use this as a quick fit check, not a diagnosis.

Worth considering if

You have mild-to-moderate generalized anxiety
You want a low-dependence option to trial for 2–4 weeks
You have no allergy to ragweed, daisies, or related plants

Probably skip if

You are allergic to Asteraceae plants
You need treatment for severe anxiety or panic disorder
You expect a strong sedative for insomnia

Evidence at a glance

generalized anxiety disorder

Good Evidence
Effect
Moderate reduction in anxiety scores
Best fit
adults with mild-to-moderate GAD
Time
Weeks

sleep quality

Limited Evidence
Effect
Small, inconsistent
Best fit
adults with mild sleep disturbance, especially with anxiety
Time
Weeks

oral mucositis (cancer treatment)

Limited Evidence
Effect
Modest
Best fit
patients undergoing chemotherapy or radiotherapy, as a mouth rinse
Time
Days to weeks

menstrual pain (dysmenorrhea)

Limited Evidence
Effect
Modest
Best fit
women with primary dysmenorrhea
Time
Within a cycle or two

Evidence for 4 uses

AI-assisted evidence assessment — talk to your doctor before relying on any single supplement.

generalized anxiety disorder

Supplement benefit
Good Evidence

A standardized Matricaria chamomilla extract (1.2% apigenin) at 1,500 mg/day reduced anxiety scores in randomized trials lasting up to 8 weeks, with effects comparable to low-dose pharmaceutical anxiolytics. Apigenin's benzodiazepine-receptor binding provides a plausible mechanism. Trials are relatively few and modest in size.

Effect size
Moderate reduction in anxiety scores
Time to effect
Weeks
Best fit
adults with mild-to-moderate GAD
Less likely
severe anxiety or panic disorder

Bottom line: Reasonable evidence for modest relief of mild-to-moderate generalized anxiety.

sleep quality

Supplement benefit
Limited Evidence

Effects on sleep are smaller and less consistent than the anxiety evidence, with some trials showing modest improvement in sleep quality and others none. Benefit may partly reflect reduced anxiety and the relaxation ritual of tea.

Effect size
Small, inconsistent
Time to effect
Weeks
Best fit
adults with mild sleep disturbance, especially with anxiety

Bottom line: May modestly aid sleep, but the effect is small and unreliable.

Evidence is mixed

Sleep trials are mixed; improvements are inconsistent and often modest compared with the anxiety data.

oral mucositis (cancer treatment)

Disease adjunct
Limited Evidence

Chamomile mouthwash has shown reduced severity of oral mucositis in some small trials of chemotherapy and radiotherapy patients. Results are mixed and study quality is variable.

Effect size
Modest
Time to effect
Days to weeks
Best fit
patients undergoing chemotherapy or radiotherapy, as a mouth rinse

Bottom line: A chamomile rinse may help reduce treatment-related mouth inflammation, but evidence is limited.

menstrual pain (dysmenorrhea)

Supplement benefit
Limited Evidence

Small trials report reduced menstrual pain intensity with chamomile, possibly via anti-inflammatory and antispasmodic activity. Studies are small and short.

Effect size
Modest
Time to effect
Within a cycle or two
Best fit
women with primary dysmenorrhea

Bottom line: May modestly reduce period pain; evidence is preliminary.

How it works

Chamomile contains a diverse mix of bioactive compounds. The most pharmacologically interesting include apigenin (a flavonoid that binds to benzodiazepine receptors in the brain), bisabolol and chamazulene (anti-inflammatory terpenes in the essential oil), and various flavonoids with antioxidant activity. Apigenin's modest benzodiazepine receptor binding likely explains chamomile's mild anxiolytic effects without the dependence potential or strong sedation of prescription anxiolytics. Clinical evidence is most established for generalized anxiety disorder, where a standardized extract (Matricaria chamomilla L. extract, M. recutita 1.2 percent apigenin) at 1,500 mg per day has shown reductions in anxiety scores comparable to low-dose pharmaceutical anxiolytics in trials lasting up to 8 weeks. Effects on sleep are smaller and less consistent than the anxiety evidence. Topical chamomile has reasonable evidence for mild skin inflammation and minor wound healing.

How to take it

1. Typical dose
500 mg standardized extract (1.2% apigenin) three times daily for anxiety
2. Timing
spread across the day for anxiety; 30–60 min before bed for sleep
3. With food
with or without food
4. Split dosing
divide across 2–3 doses for anxiety
5. How long to try
Trial 2–4 weeks for anxiety effects to build

What to track

anxiety symptom scores
sleep onset and quality
digestive comfort
any allergic skin reaction

5 commercial forms

Compare the main delivery options and what they’re best suited for.

Standardized chamomile extract (1.2 percent apigenin)

500 mg three times daily for anxiety. Look for German chamomile (Matricaria) standardization.

Standardized to apigenin content; the form used in most GAD trials.

Chamomile tea (dried flowers)

Traditional preparation. 1 to 4 cups daily. Strong infusions (steeped 10 minutes) yield more bioactive compounds.

Lower concentrated dose per cup; aromatic and pleasant.

Chamomile tincture (alcohol extract)

Traditional liquid form. 1 to 4 mL 3 times daily.

Liquid concentrated form; rapid absorption.

Topical chamomile cream or ointment

Used for skin inflammation, minor cuts, eczema. Look for 3 to 10 percent chamomile content.

Surface delivery; minimal systemic absorption.

Chamomile essential oil

Should be diluted in carrier oil before skin application. Not for ingestion without specific guidance.

Highly concentrated; topical or aromatherapy use only.

Safety

Know the common side effects, key cautions, and who should avoid it.

Common side effects

allergic reactions in Asteraceae-sensitive peopleoccasional GI upsetcontact dermatitis with topical use

Serious risks

  • rare anaphylaxis in highly allergic individuals

Who should avoid it

  • allergy to ragweed, chrysanthemums, marigolds, or daisies

Pregnancy & breastfeeding

Low-dose tea has a long history of apparent safety; medicinal extract doses have less data, so discuss with a clinician.

Interactions

warfarin and other anticoagulantsModerate

mild antiplatelet effect may add to bleeding risk

benzodiazepines and CNS depressantsModerate

may enhance sedation at high doses

CYP3A4 substrates (statins, calcium channel blockers)Minor

modest CYP3A4 inhibition may alter metabolism

antihypertensivesMinor

possible additive blood-pressure lowering

Food sources

Chamomile tea (1 cup)

Amount
~2 to 3 g dried flowers
%DV

Fresh chamomile flowers

Amount
edible but rarely consumed as food
%DV

Choosing a product

What to look for on the label — and what to be skeptical of.

Look for

standardized to apigenin (≈1.2%)
specifies German chamomile / Matricaria chamomilla
third-party tested

Be skeptical of

'cures anxiety' or 'cures insomnia'
strong sedative claims
unspecified 'calm' blends without standardization

Frequently asked questions

Does chamomile tea actually help with anxiety?

Modestly. The strongest evidence is for higher-dose standardized extracts (1,500 mg/day) in generalized anxiety disorder. Tea doses are lower but the ritual and warm beverage effect plus modest pharmacological activity can produce real subjective relief. Don't expect tea to match a high-dose extract.

Is German or Roman chamomile better?

Both have similar uses but different chemistry. German chamomile (Matricaria chamomilla) has higher apigenin and chamazulene content and is the form used in most medicinal trials. Roman chamomile (Chamaemelum nobile) is more often used in cosmetics and aromatherapy.

Can I drink chamomile tea every day?

Yes, daily use has a long historical record. Watch for allergic reactions if you have ragweed or daisy family allergies, particularly with strong infusions or extracts.

Will chamomile help me sleep?

Modestly. Effects are smaller than valerian or sedating prescription medications, but the calming ritual plus mild pharmacological activity can support sleep onset, especially in people who are mildly anxious at bedtime.

Is chamomile safe during pregnancy?

Tea in moderation is generally considered safe and has a long tradition of use. High-dose extracts have less safety data and are typically avoided. Discuss with your obstetrician if uncertain.

References by claim

generalized anxiety disorder

Mao et al., 2016PMC (2016) link

Amsterdam et al., 2009PMC (2009) link

sleep quality

Deepa et al., 2025PubMed (2025) link

Soh et al., 2025PMC (2025) link

oral mucositis (cancer treatment)

de et al., 2022PubMed (2022) link

Elhadad et al., 2022PubMed (2022) link

menstrual pain (dysmenorrhea)

Khalajinia et al., 2024PMC (2024) link

Track Chamomile with Pilora

Set up dose reminders, check interactions, and join the community in the Pilora iPhone app.

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Evidence-based·Last reviewed May 30, 2026·Evidence current as of May 30, 2026·How we grade evidence

Disclaimer: These statements have not been evaluated by the FDA. This page is educational, not a substitute for personalized medical advice. Evidence grades are AI-assisted assessments — talk to your doctor before starting any new supplement, especially if you’re pregnant, breastfeeding, on medications, or managing a chronic condition.