Trazodone Interactions

Both trazodone and 5-HTP increase central serotonin activity. Trazodone blocks the serotonin transporter and acts on 5-HT2 receptors, while 5-HTP is a direct precursor to serotonin and bypasses the normal regulation of tryptophan availability. Combining them can produce additive serotonergic effects and risk of serotonin syndrome.

Trazodone and alcohol both depress the central nervous system, producing additive sedation, dizziness, orthostatic hypotension, and impaired psychomotor performance. The combination also increases risk of falls, accidents, and rarely, dangerous arrhythmias related to QT prolongation.