Thc Interactions

Co-administration of alcohol with THC significantly increases peak blood THC and 11-OH-THC concentrations versus cannabis alone, and produces additive impairment of psychomotor performance, judgment, and reaction time.

THC and benzodiazepines are both central-nervous-system depressants and produce additive sedation, ataxia, cognitive impairment, and respiratory slowing. THC and CBD components of cannabis also inhibit CYP3A4, which metabolizes alprazolam, midazolam, and triazolam, potentially raising benzodiazepine plasma levels.