Phosphatidylserine Interactions

Phosphatidylserine and omega-3 fatty acids (especially DHA) are both core structural components of neuronal membranes, and a PS-DHA form mirrors the way the two naturally occur together in brain phospholipids. In older adults with subjective memory complaints, supplementing the pair has shown modest, mostly subgroup-level improvements in memory measures, though the strongest single figures come from small, uncontrolled studies and the placebo-controlled evidence is weaker than the synergy is sometimes presented to be.

Pairing a standardized ginkgo biloba extract with phosphatidylserine appears to improve absorption of ginkgo's active fraction. In one small placebo-controlled crossover trial, the ginkgo-phosphatidylserine complex produced modest improvements in memory performance and speed in healthy young adults, where the same dose of ginkgo alone did not.