Niacin Interactions
4 documented interactions — 1 warning, 3 beneficial pairs.
View the full Niacin supplement guide →Interaction warnings
Beneficial pairs
Niacin + tryptophan
synergyTryptophan is converted in the liver to niacin (vitamin B3) at a ratio of roughly 60 mg tryptophan to 1 mg niacin, so adequate dietary tryptophan reduces the niacin requirement and helps maintain NAD/NADP coenzyme pools. Niacin in turn spares tryptophan for serotonin and melatonin synthesis, supporting mood and sleep.
Niacin + coq10
synergyNiacin (vitamin B3) is the precursor to NAD+ and NADH, the electron carriers that feed into Complex I of the mitochondrial electron transport chain where CoQ10 shuttles those electrons toward ATP synthesis. Together they support different stages of the same energy-producing pathway.
Niacin + nad+
synergyNiacin (nicotinic acid) is a vitamin B3 precursor that the body converts to NAD+ via the Preiss-Handler pathway, so pairing oral niacin with direct NAD+ precursors can support cellular NAD+ pools through complementary biosynthetic routes. In a clinical study of mitochondrial myopathy, 1,000 mg/day niacin meaningfully raised muscle and blood NAD+.
Related ingredients
Ingredients commonly checked alongside Niacin.