Naproxen Interactions

Naproxen and alcohol combine to substantially increase the risk of stomach bleeding, ulcers, and kidney injury through additive effects on gastric mucosal damage, platelet inhibition, and reduced renal perfusion. Naproxen's longer half-life means the interaction window is more prolonged than with shorter-acting NSAIDs.

Naproxen impairs platelet aggregation through COX-1 inhibition, and fish oil EPA and DHA have mild antiplatelet and antithrombotic effects. Combining them can modestly increase bleeding risk, especially at high doses or alongside other blood thinners.