Naproxen Interactions

Naproxen is a long-acting NSAID that weakens the stomach's protective lining and blunts platelet function. Adding alcohol stacks several forms of damage on top of each other, and naproxen's long action keeps that interaction window open well beyond the last dose.

Naproxen and fish oil both mildly reduce platelet aggregation through separate pathways, so their effects are additive in theory. Pooled clinical-trial data show no meaningful increase in major bleeding at typical doses.