Lemon Balm Interactions
2 documented interactions — 0 warnings, 2 beneficial pairs.
View the full Lemon Balm supplement guide →Beneficial pairs
Lemon Balm + valerian
synergyLemon balm (Melissa officinalis) and valerian (Valeriana officinalis) both modulate the GABAergic system but through different mechanisms — valerian's valerenic acid acts directly on GABA-A receptors while lemon balm's rosmarinic acid inhibits GABA transaminase to preserve GABA in the synapse — and the combination has been studied for restlessness, dyssomnia, and sleep quality.
Lemon Balm + passionflower
synergyPassionflower (Passiflora incarnata) contains flavonoids that act as positive modulators at the GABA-A receptor benzodiazepine site, while lemon balm (Melissa officinalis) inhibits GABA transaminase, the enzyme that breaks down GABA. The two herbs raise GABAergic tone through complementary mechanisms - one boosts receptor activity, the other extends GABA's half-life - which is the basis for several traditional anxiolytic and sleep formulas.
Related ingredients
Ingredients commonly checked alongside Lemon Balm.