Ketoconazole Interactions
2 documented interactions — 2 warnings, 0 beneficial pairs.
Interaction warnings
Ketoconazole + calcium
moderateCalcium carbonate antacids raise gastric pH above the threshold that ketoconazole needs to dissolve, reducing oral ketoconazole absorption and lowering antifungal blood concentrations.
Ketoconazole + st. john's wort
moderateSt. John's Wort is a potent inducer of CYP3A4 and P-glycoprotein via PXR activation, which can accelerate the metabolism of ketoconazole and reduce its antifungal blood concentrations and clinical effectiveness.
Related ingredients
Ingredients commonly checked alongside Ketoconazole.