Glutathione Interactions

NAC (N-acetylcysteine) provides the rate-limiting cysteine substrate the body uses to synthesize new glutathione intracellularly, while supplemental glutathione directly replenishes the circulating and extracellular pool. The two work through complementary upstream-and-downstream mechanisms to support antioxidant defense and phase II liver detoxification.

Vitamin C reduces oxidized glutathione (GSSG) back to reduced glutathione (GSH) via the ascorbate-glutathione cycle, while glutathione in turn regenerates oxidized vitamin C (dehydroascorbate) back to ascorbate. The two antioxidants mutually recycle each other and maintain cellular redox balance.