Clobazam Interactions

1 documented interaction — 1 warning, 0 beneficial pairs.

Interaction warnings

Clobazam + cbd

high

CBD strongly inhibits CYP2C19, the enzyme that clears N-desmethylclobazam (the active metabolite of clobazam). Co-administration triples plasma N-desmethylclobazam levels, causing excess sedation, ataxia, and somnolence; this is documented in the FDA-approved Epidiolex prescribing information.

Related ingredients

Ingredients commonly checked alongside Clobazam.

Cbd(1)
← Browse all interactions
Clobazam Interactions | Pilora