Ciprofloxacin Interactions

Ciprofloxacin is a potent CYP1A2 inhibitor. Co-administration increases caffeine's area-under-the-curve by 50-100% and prolongs its half-life, producing exaggerated central nervous system and cardiovascular stimulation.

Ciprofloxacin is a potent inhibitor of CYP1A2, the enzyme that metabolizes caffeine. Co-administration can reduce caffeine clearance by 30% to 50% and prolong its half-life, leading to higher plasma caffeine levels, jitteriness, insomnia, palpitations, tremor, and (rarely) seizures.