Boswellia Interactions

Curcumin inhibits NF-kB and dampens COX-2 transcription while boswellic acids (particularly AKBA) selectively block 5-lipoxygenase and leukotriene synthesis. Together they suppress two non-overlapping arms of the inflammatory cascade, giving better symptom relief in osteoarthritis than either alone.

Boswellic acids inhibit 5-lipoxygenase to block pro-inflammatory leukotrienes, while EPA and DHA from omega-3s reduce arachidonic acid availability and serve as substrates for specialized pro-resolving mediators (resolvins, protectins) that actively turn off inflammation. The two ingredients suppress inflammation at different steps of the same lipid cascade, giving complementary anti-inflammatory coverage.