Beetroot Interactions

Nitroglycerin releases nitric oxide to dilate blood vessels and relieve angina. Beetroot is the most concentrated dietary source of inorganic nitrate, which the body also converts to nitric oxide, so combining the two can cause additive vasodilation, low blood pressure, headache, and fainting.

Tadalafil inhibits PDE5 for up to 36 hours, prolonging the vasodilatory effect of any nitric oxide pathway activation. Beetroot's dietary nitrate becomes nitric oxide in the body and can add to tadalafil's blood pressure lowering, particularly with concentrated beetroot shots or supplements.

Vardenafil blocks PDE5 and prolongs nitric oxide signaling. Beetroot is a major dietary source of nitrate that the body converts to nitric oxide, so concentrated beetroot products can add to vardenafil's blood pressure lowering effect.

Beetroot is high in dietary inorganic nitrate that the body converts to nitric oxide, the same vasodilator pathway amplified by PDE5 inhibitors like sildenafil. While organic nitrate drugs (not dietary) are the formal contraindication, large doses of beetroot juice can meaningfully lower blood pressure and may add to sildenafil's vasodilatory effect.