Ophiopogon

botanical

At a glance

Best for
no standalone use is supported by good human trials
Typical dose
no well-established single-herb clinical dose
Time to effect
Not established
Main caution
evidence comes mostly from multi-herb formulas and animal models
Evidence strength: Very low for the isolated herb; mostly preclinical/TCM

What is it

Ophiopogon (Ophiopogon japonicus), known as Mai Dong or dwarf lilyturf, is a plant whose tuberous roots are a common ingredient in traditional Chinese medicine. It is used traditionally to 'moisten' dryness, for cough, and as part of cardiovascular formulas, and contains saponins (ophiopogonins) and polysaccharides. Almost all supporting evidence is preclinical or from multi-herb formulas rather than the isolated herb.

Is it worth it for you?

Worth considering if…

  • You are using it within a clinician-guided traditional formula and accept limited evidence

Probably skip if…

  • You want a single-ingredient remedy with proven benefit
  • You expect cardiovascular or respiratory treatment effects from the isolated herb

Evidence at a glance

GoalEvidenceEffectBest fitTime
cardiovascular support (traditional / formula-based)MixedNot establishednone established for the isolated herbNot established

Evidence for 1 use

AI-assisted evidence assessment — talk to your doctor before relying on any single supplement.

cardiovascular support (traditional / formula-based)

Mechanism only
Mixed

Ophiopogon is a component of traditional cardiovascular formulas (such as Sheng Mai San), and animal and cell studies report antioxidant, anti-inflammatory, and myocardial-protective activity for its ophiopogonins and polysaccharides. Human evidence is largely confined to multi-herb formulas, making it impossible to attribute any effect to ophiopogon alone. This is mechanistic and formula-level evidence, not isolated-herb clinical proof.

Effect size: Not established
Time to effect: Not established
Best fit: none established for the isolated herb

Bottom line: Cardiovascular use rests on preclinical data and multi-herb formulas, not on the isolated herb.

How to take it

Typical dose
No standardized single-herb dose; traditionally used within decoctions/formulas
Timing
Not established
With food
Not established
How long to try
Not established

What to track

  • Whatever symptom is targeted
  • Any GI upset or interactions

Safety

Common side effects

Generally regarded as well tolerated traditionally, Possible GI upset

Who should avoid it

  • Pregnant or breastfeeding people (insufficient data)
  • Anyone needing evidence-based treatment

Pregnancy & breastfeeding

No reliable safety data in pregnancy or breastfeeding; avoid medicinal use.

Choosing a product

Look for

  • Correct species (Ophiopogon japonicus)
  • Named plant part (root/tuber)
  • Third-party identity testing

Be skeptical of

  • Cardiovascular or heart-disease treatment claims
  • Implied proven benefit from the single herb
  • 'Yin-tonifying cure-all' marketing

References by claim

cardiovascular support (traditional / formula-based)

  • Chen et al., 2016PubMed (2016) link
  • Fang et al., 2018PubMed (2018) link

Track Ophiopogon with Pilora

Set up dose reminders, check interactions, and join the community in the Pilora iPhone app.

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Evidence-based·Last reviewed May 30, 2026·Evidence current as of May 30, 2026·How we grade evidence

Disclaimer: These statements have not been evaluated by the FDA. This page is educational, not a substitute for personalized medical advice. Evidence grades are AI-assisted assessments — talk to your doctor before starting any new supplement, especially if you’re pregnant, breastfeeding, on medications, or managing a chronic condition.