Maytenus ilicifolia

Evidence: Limited
Botanical

Useful mainly for people with functional dyspepsia or mild gastritis seeking a traditional remedy.

Quick decision guide

May help most

People with functional dyspepsia or mild gastritis seeking a traditional remedy

Common dosing range

300–900 mg/day of leaf extract; ~400 mg common

When to expect effects

Days to weeks

Watch out for

Human evidence is thin; not a substitute for ulcer treatment

What is it

Maytenus ilicifolia, known in Brazil as espinheira-santa, is a South American shrub whose leaves are used traditionally for dyspepsia, gastritis, and ulcers. It is one of the better-documented traditional gastric remedies, though high-quality human trials are limited.

Is it worth it for you?

Use this as a quick fit check, not a diagnosis.

Worth considering if

You have functional dyspepsia or mild gastric discomfort
You want a traditional botantical antacid alternative and tolerate it well

Probably skip if

You have a diagnosed ulcer needing standard therapy
You want robust clinical-trial backing
You are pregnant or trying to conceive

Evidence at a glance

GoalEvidenceEffectBest fitTime
dyspepsia and gastric protectionLimitedModest symptom reliefAdults with functional dyspepsia or mild gastritisDays to weeks

Evidence for 1 use

AI-assisted evidence assessment — talk to your doctor before relying on any single supplement.

dyspepsia and gastric protection

Supplement benefit
Limited

Espinheira-santa has a long traditional use for dyspepsia and ulcers, and animal studies show antacid and gastroprotective (anti-ulcer) activity. Direct controlled human trials are sparse, so symptom relief is plausible and traditionally supported but not firmly established.

Effect size: Modest symptom relief
Time to effect: Days to weeks
Best fit: Adults with functional dyspepsia or mild gastritis

Bottom line: A traditionally supported option for mild dyspepsia, with limited but consistent preclinical backing.

How to take it

Typical dose
300–900 mg/day of leaf extract
Timing
Commonly taken before meals
With food
Before meals; also taken as a leaf tea traditionally
How long to try
Trial 2–4 weeks for dyspepsia symptoms

What to track

  • Upper-abdominal discomfort
  • Heartburn or fullness after meals
  • Nausea

Safety

Common side effects

Generally well tolerated, Occasional dry mouth or mild GI upset

Who should avoid it

  • Pregnant or breastfeeding people
  • Those trying to conceive (traditional contraceptive/abortifacient use reported)

Pregnancy & breastfeeding

Avoid — traditional reports of anti-fertility and abortifacient effects; not enough safety data.

Interactions

antacids and acid-reducing drugsMinor

Overlapping effect on gastric acidity; generally additive rather than harmful

Choosing a product

Look for

  • Identifies species as Maytenus ilicifolia and leaf part
  • Third-party tested for identity and contaminants

Be skeptical of

  • “Cures ulcers”
  • “Eradicates H. pylori”
  • Replaces prescribed gastric therapy

References by claim

dyspepsia and gastric protection

  • Baggio et al., 2007PubMed (2007) link
  • da et al., 2015PubMed (2015) link

Track Maytenus ilicifolia with Pilora

Set up dose reminders, check interactions, and join the community in the Pilora iPhone app.

Coming to App Store
Evidence-based·Last reviewed May 30, 2026·Evidence current as of May 30, 2026·How we grade evidence

Disclaimer: These statements have not been evaluated by the FDA. This page is educational, not a substitute for personalized medical advice. Evidence grades are AI-assisted assessments — talk to your doctor before starting any new supplement, especially if you’re pregnant, breastfeeding, on medications, or managing a chronic condition.