Lysophosphatidic acid

Fatty-acidPhospholipid

What is it

Lysophosphatidic acid (LPA) is a bioactive glycerophospholipid signaling molecule produced in the body from phosphatidic acid and lysophospholipids. It functions as an autocrine and paracrine signal through specific G-protein-coupled receptors.

Evidence for 1 use

AI-assisted evidence assessment — talk to your doctor before relying on any single supplement.

Endogenous signaling lipid

Mixed Evidence

LPA is a biological signaling molecule, not a supplement with established benefit.

How it works

LPA signals through at least six receptor subtypes (LPA1-LPA6), regulating cell proliferation, migration, differentiation, smooth muscle contraction, and wound healing. It is produced extracellularly by autotaxin (ENPP2) acting on lysophosphatidylcholine. Most research interest is in LPA's role as an endogenous signaling lipid, with drug discovery focused on antagonists for fibrotic and oncologic conditions. There is no established dietary or supplement use for LPA itself.

Dosage

There is no supplement use of LPA with established human evidence.

When and how to take it

Not applicable.

1 commercial form

Compare the main delivery options and what they’re best suited for.

Endogenous lipid mediator

Pharmacologic interest is in receptor antagonists, not supplementation.

Not used as oral supplement.

Safety

Exogenous LPA is not used in human supplementation. Pharmacologic manipulation of LPA pathways is investigational.

Who should be cautious

Not a supplement ingredient.

Interactions

Not applicable as a supplement.

Frequently asked questions

Can I take LPA as a supplement?⌄

No. There is no established oral supplement use of lysophosphatidic acid.

References

Lysophosphatidic acid on Wikidata — Wikidata link

Lysophosphatidic acid (PubChem CID 5497152) — PubChem link

Lysophosphatidic acid on NIH DSLD (US supplement label database) — NIH Dietary Supplement Label Database link

Research on Lysophosphatidic acid (PubMed search) — PubMed link

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Evidence-based·How we grade evidence

Disclaimer: These statements have not been evaluated by the FDA. This page is educational, not a substitute for personalized medical advice. Evidence grades are AI-assisted assessments — talk to your doctor before starting any new supplement, especially if you’re pregnant, breastfeeding, on medications, or managing a chronic condition.