Kaempferide

PhytochemicalFlavonoid

What is it

Kaempferide (kaempferol 4'-methyl ether) is a methylated flavonol found in propolis, certain alpinia species, and other plants. It is a relative of kaempferol.

Evidence for 1 use

AI-assisted evidence assessment — talk to your doctor before relying on any single supplement.

Antioxidant / anti-inflammatory (preclinical)

Mixed Evidence

Laboratory activity has been demonstrated; no human clinical trials of isolated kaempferide support specific use.

How it works

Kaempferide shows antioxidant, anti-inflammatory, and antitumor activity in cell and animal models, with mechanisms including inhibition of NF-kB and STAT3 signaling pathways. Methylation tends to improve membrane permeability and metabolic stability compared with the parent kaempferol. Human clinical evidence for isolated kaempferide is essentially absent. Dietary exposure occurs mainly through propolis and certain herbal sources.

Dosage

There is no established evidence-based dose. DSLD label data does not provide a usable median.

When and how to take it

No evidence-based timing.

1 commercial form

Compare the main delivery options and what they’re best suited for.

Propolis or plant extract constituent

Typical exposure source.

Methylated flavonols generally have better oral absorption than parent forms.

Safety

Limited safety data on isolated kaempferide in humans. Propolis (a common source) can cause allergic contact reactions in susceptible people.

Who should be cautious

Pregnancy and breastfeeding safety unknown. Propolis-allergic individuals should avoid propolis-derived products.

Interactions

Potential theoretical interactions with CYP-metabolized drugs based on in vitro flavonoid activity. Not clinically established.

Food sources

Propolis

Amount
Variable
%DV
—

Frequently asked questions

Is kaempferide the same as kaempferol?⌄

They are related; kaempferide is the methylated derivative of kaempferol.

References

Kaempferide on Wikidata — Wikidata link

Kaempferide (ChEBI:6099) — ChEBI link

Kaempferide (PubChem CID 5281666) — PubChem link

Kaempferide on NIH DSLD (US supplement label database) — NIH Dietary Supplement Label Database link

Research on Kaempferide (PubMed search) — PubMed link

Track Kaempferide with Pilora

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Evidence-based·How we grade evidence

Disclaimer: These statements have not been evaluated by the FDA. This page is educational, not a substitute for personalized medical advice. Evidence grades are AI-assisted assessments — talk to your doctor before starting any new supplement, especially if you’re pregnant, breastfeeding, on medications, or managing a chronic condition.