Isovitexin

PhytochemicalFlavonoidBest before bed

What is it

Isovitexin (apigenin-6-C-glucoside) is a C-glycoside flavone, an isomer of vitexin. It is found in passionflower, bamboo leaves, oats, mung beans, and rice hulls.

Evidence for 1 use

AI-assisted evidence assessment — talk to your doctor before relying on any single supplement.

Anxiety / sleep (via passionflower)

Limited Evidence

Small RCTs of passionflower (containing isovitexin) show modest benefit; isolated isovitexin is unstudied in humans.

How it works

Isovitexin shows antioxidant, anti-inflammatory, and anxiolytic activity in cell and animal models. The flavone aglycone derived from gut metabolism (apigenin) is the main active. Its presence in passionflower extract may contribute to that herb's calming effects via GABA-A receptor modulation. Stand-alone human evidence is essentially absent.

Dosage

Not commonly dosed as an isolated supplement. Passionflower extracts standardized to isovitexin or total flavones are dosed at 300-900 mg/day.

When and how to take it

Take in the evening if used for sleep or anxiety.

1 commercial form

Compare the main delivery options and what they’re best suited for.

Passionflower extract

Most common real-world source.

Standardized blend of flavones.

Safety

Standardized passionflower extracts are well tolerated. Pure isovitexin lacks human safety data.

Who should be cautious

Pregnancy: avoid passionflower extracts due to limited data. Concurrent sedative use: discuss with prescriber.

Interactions

Through its parent extract passionflower, may potentiate sedatives.

Food sources

Passionflower tea

Amount
small amount of mixed flavones
%DV
—

Mung beans (1 cup)

Amount
trace isovitexin
%DV
—

Frequently asked questions

What is isovitexin in my passionflower supplement?⌄

It's a marker flavone used for standardization; the whole-extract effect is what matters.

Is it safe?⌄

At passionflower-extract doses, yes. Pure isovitexin is not well studied.

References

Isovitexin on Wikidata — Wikidata link

Isovitexin (ChEBI:18330) — ChEBI link

Isovitexin (PubChem CID 162350) — PubChem link

Isovitexin on NIH DSLD (US supplement label database) — NIH Dietary Supplement Label Database link

Research on Isovitexin (PubMed search) — PubMed link

Track Isovitexin with Pilora

Set up dose reminders, check interactions, and join the community in the Pilora iPhone app.

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Evidence-based·How we grade evidence

Disclaimer: These statements have not been evaluated by the FDA. This page is educational, not a substitute for personalized medical advice. Evidence grades are AI-assisted assessments — talk to your doctor before starting any new supplement, especially if you’re pregnant, breastfeeding, on medications, or managing a chronic condition.