Isopropyloctopamine

PhytochemicalPhenethylamine

What is it

Isopropyloctopamine (often as the HCl salt, also known as deterenol) is a synthetic beta-adrenergic stimulant found in some pre-workout and weight-loss supplements. It is not a naturally occurring nutrient.

Evidence for 1 use

AI-assisted evidence assessment — talk to your doctor before relying on any single supplement.

None established

Mixed Evidence

No human clinical evidence supports safe or effective use as a supplement. FDA has warned against its presence in supplements.

How it works

Isopropyloctopamine is a synthetic phenethylamine that stimulates beta-adrenergic receptors. It raises heart rate, blood pressure, and metabolic rate. It is not approved for human use as a medication. The FDA has issued warnings about its presence in dietary supplements, citing safety concerns and lack of evidence supporting its safe use.

Dosage

There is no medically established dose. Use in supplements is associated with safety risks.

When and how to take it

Use is not recommended. If found in a product label, it is a sign of a potentially adulterated or unsafe supplement.

1 commercial form

Compare the main delivery options and what they’re best suited for.

Isopropyloctopamine HCl (deterenol)

Found illicitly in some weight-loss and pre-workout products.

Synthetic stimulant

Safety

FDA has identified isopropyloctopamine as an unsafe ingredient in dietary supplements. It has been associated with cardiovascular adverse events, including hypertension, arrhythmias, and cardiovascular events in users.

Who should be cautious

Should be avoided by everyone, especially those with cardiovascular disease, hypertension, diabetes, or who are pregnant or breastfeeding. Banned by sports anti-doping agencies.

Interactions

Significant interactions with stimulants, MAO inhibitors, antidepressants, blood pressure medications, and sympathomimetic agents. Combination with other stimulants can be dangerous.

Frequently asked questions

Is isopropyloctopamine legal in supplements?⌄

No. The FDA has warned against its use in dietary supplements. Products containing it may be in violation of US law.

Is it safe?⌄

No. It has been associated with cardiovascular adverse events. Avoid products containing it.

References

Isopropyloctopamine on NIH DSLD (US supplement label database) — NIH Dietary Supplement Label Database link

Research on Isopropyloctopamine (PubMed search) — PubMed link

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Evidence-based·How we grade evidence

Disclaimer: These statements have not been evaluated by the FDA. This page is educational, not a substitute for personalized medical advice. Evidence grades are AI-assisted assessments — talk to your doctor before starting any new supplement, especially if you’re pregnant, breastfeeding, on medications, or managing a chronic condition.