Isopropylnorsynephrine

PhytochemicalAlkaloid

What is it

Isopropylnorsynephrine (deterenol) is a synthetic sympathomimetic compound structurally related to synephrine, sold in some pre-workout and fat-burner supplements despite not being approved as a dietary ingredient by FDA.

How it works

It acts as an adrenergic agonist, stimulating beta-receptors and increasing cardiac output, blood pressure, and energy expenditure. It is not a naturally occurring botanical compound; products labeling it as a 'natural extract' have repeatedly been challenged by FDA and academic analyses. FDA has issued warnings about deterenol and considers it an unapproved ingredient in dietary supplements.

Dosage

There is no safe, established dose; the compound has no approved dietary supplement use. DSLD does not provide a median dose for this entry.

When and how to take it

Not recommended for any timing. Use in dietary supplements is not lawful in the US.

1 commercial form

Compare the main delivery options and what they’re best suited for.

Isopropylnorsynephrine HCl

Found in some pre-workouts and fat-burners despite regulatory status.

Orally active sympathomimetic salt.

Safety

Adverse events reported include rapid heart rate, high blood pressure, chest pain, nausea, and serious cardiac events. FDA has flagged this ingredient as not a legitimate dietary ingredient.

Who should be cautious

Avoid in cardiovascular disease, hypertension, arrhythmias, thyroid disease, pregnancy, breastfeeding, and in anyone under 18. Best avoided by everyone given regulatory status.

Interactions

Should not be combined with other stimulants (caffeine in high doses, yohimbine), MAOIs, decongestants, or stimulant ADHD medications.

Frequently asked questions

Is isopropylnorsynephrine legal in supplements?⌄

FDA considers it an unapproved ingredient in dietary supplements and has warned manufacturers about its use.

Is it dangerous?⌄

It is a stimulant linked to serious cardiovascular adverse events; avoid use.

References

Isopropylnorsynephrine on Wikidata — Wikidata link

Isopropylnorsynephrine (PubChem CID 23843) — PubChem link

Isopropylnorsynephrine on NIH DSLD (US supplement label database) — NIH Dietary Supplement Label Database link

Research on Isopropylnorsynephrine (PubMed search) — PubMed link

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Evidence-based·How we grade evidence

Disclaimer: These statements have not been evaluated by the FDA. This page is educational, not a substitute for personalized medical advice. Evidence grades are AI-assisted assessments — talk to your doctor before starting any new supplement, especially if you’re pregnant, breastfeeding, on medications, or managing a chronic condition.