Hesperidin methylchalcone

PhytochemicalFlavonoidBest with a meal

What is it

Hesperidin methylchalcone (HMC) is a semi-synthetic flavonoid derived from hesperidin, used in venoactive products for chronic venous insufficiency and hemorrhoid symptoms, often combined with diosmin and Ruscus aculeatus extract.

Evidence for 1 use

AI-assisted evidence assessment — talk to your doctor before relying on any single supplement.

Chronic venous insufficiency / hemorrhoids

Good Evidence

Combination venoactive products containing HMC show symptom improvements in trials for chronic venous insufficiency and acute hemorrhoidal flares.

How it works

HMC is part of a class of venoactive flavonoids that increase venous tone, reduce capillary permeability, and improve lymphatic drainage. It is most commonly used in combination products with diosmin and butcher's broom for symptoms of heavy legs, edema, and hemorrhoidal flares. Mechanistic studies attribute effects to inhibition of inflammatory mediators and protection of vascular endothelium.

Dosage

There is no RDA. Combination venoactive products typically contain HMC at 150-300 mg/day. DSLD does not provide a median dose for this entry.

When and how to take it

Take with food in 1-2 divided doses. Daily use over 4-12 weeks is typical for venous symptoms.

1 commercial form

Compare the main delivery options and what they’re best suited for.

Hesperidin methylchalcone (often combined)

Found in venoactive combination products.

Modified flavonoid; absorption better than parent hesperidin.

Safety

Generally well tolerated. GI symptoms and mild headache are most common side effects in trials.

Who should be cautious

Pregnancy and breastfeeding: data on combination venoactive products are limited; many guidelines avoid in first trimester.

Interactions

No major clinically documented interactions. Theoretical mild interaction with anticoagulants based on flavonoid activity.

Frequently asked questions

Is HMC the same as hesperidin?⌄

No. HMC is a chemically modified derivative with different absorption characteristics.

Will it cure varicose veins?⌄

It can reduce symptoms (heaviness, swelling) but does not reverse established varicose veins.

References

Hesperidin methylchalcone on Wikidata — Wikidata link

Hesperidin methylchalcone (PubChem CID 6436550) — PubChem link

Hesperidin methylchalcone on NIH DSLD (US supplement label database) — NIH Dietary Supplement Label Database link

Research on Hesperidin methylchalcone (PubMed search) — PubMed link

Track Hesperidin methylchalcone with Pilora

Set up dose reminders, check interactions, and join the community in the Pilora iPhone app.

Coming to App Store
Evidence-based·How we grade evidence

Disclaimer: These statements have not been evaluated by the FDA. This page is educational, not a substitute for personalized medical advice. Evidence grades are AI-assisted assessments — talk to your doctor before starting any new supplement, especially if you’re pregnant, breastfeeding, on medications, or managing a chronic condition.