Gotu Kola

Gotu kola contains triterpene saponins, particularly asiaticoside, madecassoside, asiatic acid, and madecassic acid, collectively called centellosides. These compounds are thought to stimulate collagen synthesis, support extracellular matrix integrity, and improve microcirculation, which underlies traditional use for wound healing and venous insufficiency. Clinical research has been most extensive for chronic venous insufficiency, where standardized extracts have shown modest improvement in symptoms like leg heaviness, swelling, and capillary fragility. The mechanism appears to involve effects on vascular permeability and collagen synthesis in vessel walls. For cognitive applications, gotu kola has been studied in older adults and in stress conditions, with some small trials suggesting modest improvements in memory, attention, or mood. Proposed mechanisms include antioxidant effects, modulation of acetylcholinesterase, and possible effects on neurogenesis. Topical applications have been studied for scar improvement and wound healing.

There is no established RDA. Traditional dried herb preparations use 1 to 4 grams per day. Standardized extracts (often labeled 'titrated extract of Centella asiatica' or TECA) are commonly dosed at 60 to 180 mg per day, providing standardized total triterpene content. For chronic venous insufficiency, clinical trials have used 60 to 180 mg of standardized extract daily.

Gotu kola can be taken with or without food. For chronic venous insufficiency, doses are typically divided two or three times daily, with effects emerging over 4 to 8 weeks. For cognitive applications, daily use over weeks to months is typical. Topical applications for wounds or scars are used directly on the affected area, following product instructions.

Gotu kola is generally well tolerated at typical doses. Side effects can include nausea, stomach upset, drowsiness, and contact dermatitis (especially with topical use). Rare reports of liver injury have been published, though causality is debated and many cases involved multiple supplements or pre-existing conditions. There is no established Tolerable Upper Intake Level. Long-term high-dose use has not been thoroughly studied.

Gotu kola may potentiate CNS depressants and sedatives. Possible interactions with hepatotoxic medications. May affect cholesterol-lowering medications. May enhance the effects of diabetes medications. Some animal data suggest possible effects on liver enzymes, with theoretical interactions with drugs metabolized by the liver.