Exopeptidase

Exopeptidases work by trimming individual amino acids from either the amino-terminal (aminopeptidases) or carboxyl-terminal (carboxypeptidases) end of peptide chains. They complement endopeptidases, which cut proteins in the middle, allowing fuller breakdown of dietary protein into free amino acids and small peptides that can be absorbed. In supplements, exopeptidases are usually derived from fungal sources such as Aspergillus oryzae and are often included in proteolytic enzyme blends for digestion. Some formulations also include DPP-IV (a specific exopeptidase) targeted at gluten and casein peptides.

No established RDA. Supplement doses are typically expressed in activity units (HUT, PC, DPPU) rather than milligrams, and vary by formulation. Single-meal doses commonly fall in the 5,000 to 50,000 HUT range as part of broader enzyme blends.

Take with meals containing protein so the enzymes are present when food enters the stomach and small intestine. Splitting a dose across larger meals is reasonable.

Generally well tolerated. Mild gastrointestinal upset, bloating, or loose stools may occur. People with known allergies to mold or Aspergillus-derived products should choose carefully. Long-term safety data in supplement settings is limited.

No well-documented interactions with prescription medications, though digestive enzymes can theoretically alter absorption of co-ingested drugs. Discuss with a clinician if you take medications with narrow therapeutic windows.