Eurycomanone

PhytochemicalQuassinoidBest in the morningBest taken with food

What is it

Eurycomanone is a quassinoid compound from Eurycoma longifolia (tongkat ali) root and is considered one of the key bioactives in standardized tongkat ali extracts marketed for male hormonal and athletic support.

Evidence for 1 use

AI-assisted evidence assessment — talk to your doctor before relying on any single supplement.

Stress and hormonal balance (via tongkat ali extracts)

Limited Evidence

Small RCTs of standardized tongkat ali extracts suggest reductions in stress markers and modest hormonal changes. Effect sizes are small; isolated eurycomanone is not separately well studied in humans.

How it works

Eurycomanone has been reported in preclinical studies to inhibit aromatase, support testosterone biosynthesis, and reduce stress-related cortisol elevations. The clinically studied form is a standardized tongkat ali extract (e.g., Physta) rather than isolated eurycomanone. Small human trials of standardized extracts suggest modest improvements in stress markers, hormonal balance, and exercise-related parameters in some populations.

Dosage

There is no RDA. Standardized tongkat ali extracts are typically dosed at 200-400 mg/day, often standardized to ~1-2% eurycomanone. DSLD does not provide a median dose for this entry.

When and how to take it

Take with food, earlier in the day, to reduce risk of sleep disturbance. Daily use over weeks is needed to assess effects.

1 commercial form

Compare the main delivery options and what they’re best suited for.

Tongkat ali extract standardized to eurycomanone

Look for clinically used standardized extracts.

Standardization of eurycomanone percentage varies by brand.

Safety

Generally well tolerated in short-term studies at typical doses. Higher doses have been associated with mild insomnia and irritability in some users. Long-term safety data are limited.

Who should be cautious

Avoid in pregnancy and breastfeeding. Avoid in hormone-sensitive cancers without specialist guidance. Caution in chronic insomnia and in patients on hormonal medications.

Interactions

Theoretical interactions with hormone therapies, aromatase inhibitors, and antidiabetic drugs. Some products may have additive stimulant-like effects.

Frequently asked questions

Does eurycomanone raise testosterone?⌄

Small studies of standardized tongkat ali extracts suggest modest hormonal effects, primarily in men with lower baseline levels.

Is it safe for women?⌄

Most clinical work is in men. Women and people with hormone-sensitive conditions should consult a clinician before use.

References

Eurycomanone on Wikidata — Wikidata link

Eurycomanone on NIH DSLD (US supplement label database) — NIH Dietary Supplement Label Database link

Research on Eurycomanone (PubMed search) — PubMed link

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Evidence-based·How we grade evidence

Disclaimer: These statements have not been evaluated by the FDA. This page is educational, not a substitute for personalized medical advice. Evidence grades are AI-assisted assessments — talk to your doctor before starting any new supplement, especially if you’re pregnant, breastfeeding, on medications, or managing a chronic condition.