Eleutheroside

PhytochemicalGlycosideBest in the afternoon

What is it

Eleutherosides are a chemically diverse group of marker compounds found in Eleutherococcus senticosus (Siberian ginseng) root, including syringin (B), syringaresinol diglucoside (E), and others.

Evidence for 1 use

AI-assisted evidence assessment — talk to your doctor before relying on any single supplement.

Standardization marker

Limited Evidence

Used to verify eleuthero potency; isolated trials are absent.

How it works

Eleutherosides B and E are the most studied and serve as the standard for eleuthero product potency. They appear to contribute to adaptogenic effects through HPA axis and immune modulation seen in animal and limited human studies. The specific mechanism is not fully characterized. Individual eleutherosides are not typically sold in isolation; they are used to standardize whole eleuthero extracts.

Dosage

No RDA. Standardized eleuthero extracts deliver 2-10 mg of combined eleutherosides B and E per typical 300-1200 mg dose.

When and how to take it

WHEN: Morning or early afternoon. HOW: Take within a standardized eleuthero extract.

1 commercial form

Compare the main delivery options and what they’re best suited for.

Within standardized eleuthero extract

Not sold individually.

Eleutherosides are absorbed.

Safety

Profile mirrors the whole eleuthero extract.

Who should be cautious

Caution in uncontrolled hypertension, cardiovascular disease, and pregnancy.

Interactions

Inherited from eleuthero extract: possible interactions with digoxin assays, sedatives, and hypoglycemics.

Frequently asked questions

What does 0.8% eleutherosides mean?⌄

A standardization spec; the extract contains 0.8% by weight of the marker eleutherosides B and E.

References

Eleutheroside on Wikidata — Wikidata link

Eleutheroside on NIH DSLD (US supplement label database) — NIH Dietary Supplement Label Database link

Research on Eleutheroside (PubMed search) — PubMed link

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Evidence-based·How we grade evidence

Disclaimer: These statements have not been evaluated by the FDA. This page is educational, not a substitute for personalized medical advice. Evidence grades are AI-assisted assessments — talk to your doctor before starting any new supplement, especially if you’re pregnant, breastfeeding, on medications, or managing a chronic condition.