E-Viniferin

PhytochemicalStilbenoidBest with a meal

What is it

E-Viniferin (epsilon-viniferin) is a resveratrol dimer found in grapevines, grape stems, and other Vitis species. It is a stilbenoid compound related to resveratrol and is sold as a concentrated supplement extract.

How it works

Like resveratrol, e-viniferin acts as an antioxidant and has been studied for effects on sirtuin signaling, mitochondrial activity, and adipocyte differentiation. Some preclinical work suggests it is more potent than resveratrol on certain endpoints, but human clinical data are limited.

Dosage

No standardized dose. Supplements often combine e-viniferin with resveratrol; total stilbenoid content varies widely (often 100-500 mg/day of combined stilbenes).

When and how to take it

Stilbenoid absorption improves with fat-containing meals. Take with food.

1 commercial form

Compare the main delivery options and what they’re best suited for.

Standardized grape stem or vine extract

Most common commercial format; standardized to a percentage of total stilbenes.

Stilbenoid absorption is relatively low; food improves uptake

Safety

Limited published human safety data for isolated e-viniferin. Polyphenol blends including viniferin are generally well tolerated at typical supplement doses.

Who should be cautious

Avoid in pregnancy and breastfeeding due to limited data. Caution in hormone-sensitive conditions because of structural similarity to other polyphenols with weak estrogenic activity.

Interactions

Stilbenes may inhibit some cytochrome P450 enzymes in vitro. Clinical interactions are not well documented but caution is reasonable with drugs metabolized by CYP3A4 or CYP2C9.

Food sources

Grape stems and skins

Amount
variable
%DV
—

Vitis vinifera vine extracts

Amount
concentrated
%DV
—

Frequently asked questions

Is e-viniferin the same as resveratrol?⌄

No. E-viniferin is a dimer of two resveratrol molecules with related but distinct activity.

Is it more potent than resveratrol?⌄

Preclinical work suggests greater potency on some endpoints. Human evidence to confirm clinical benefits is limited.

References

E-Viniferin on NIH DSLD (US supplement label database) — NIH Dietary Supplement Label Database link

Research on E-Viniferin (PubMed search) — PubMed link

Track E-Viniferin with Pilora

Set up dose reminders, check interactions, and join the community in the Pilora iPhone app.

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Evidence-based·How we grade evidence

Disclaimer: These statements have not been evaluated by the FDA. This page is educational, not a substitute for personalized medical advice. Evidence grades are AI-assisted assessments — talk to your doctor before starting any new supplement, especially if you’re pregnant, breastfeeding, on medications, or managing a chronic condition.