Evidence-based·Last reviewed May 30, 2026·How we grade evidence

DMG (Dimethylglycine)

Botanical

Useful mainly for no use is well supported by controlled trials.

Quick decision guide

May help most

no use is well supported by controlled trials

Common dosing range

100–250 mg/day (marketed ranges)

When to expect effects

Not established

Watch out for

do not confuse with 'pangamic acid/B15' products of dubious composition

What is it

Dimethylglycine (DMG) is a naturally occurring amino acid derivative formed during choline and one-carbon metabolism. It is sold as a supplement promoted for athletic performance, immune support, and behavior, often as the calcium salt. Despite long-standing marketing, controlled human evidence for these uses is weak.

Is it worth it for you?

Use this as a quick fit check, not a diagnosis.

Worth considering if…

You accept it is largely unproven and want to experiment cheaply

Probably skip if…

You want evidence-based performance or immune benefits
You are treating autism — controlled trials did not support it
You expect oxygen-utilization or endurance gains

Evidence at a glance

autism spectrum behavior

Mixed Evidence
Effect
No benefit over placebo
Best fit
none established
Time
Not established

Evidence for 1 use

AI-assisted evidence assessment — talk to your doctor before relying on any single supplement.

autism spectrum behavior

Supplement benefit
Mixed Evidence

Small randomized, placebo-controlled trials of DMG in autistic children found no significant improvement in behavior or communication over placebo. Despite persistent anecdotal use, the controlled evidence is negative.

Effect size
No benefit over placebo
Time to effect
Not established
Best fit
none established
Less likely
children with autism spectrum disorder

Bottom line: Placebo-controlled trials show no behavioral benefit in autism.

Evidence is mixed

Anecdotal reports and some parent surveys claim improvement, but randomized controlled trials did not confirm any effect.

SourceKern et al., 2001 — PubMed· conflictingKato et al., 2021 — PMC· conflicting
SourceKern et al., 2001 — PubMedKato et al., 2021 — PMC

How to take it

1. Typical dose
Commonly 100–250 mg/day
2. Timing
Any time of day
3. With food
With or without food
4. How long to try
No established trial duration; reassess after a few weeks if used

What to track

Whatever symptom you are targeting
Any GI or behavioral changes

Safety

Know the common side effects, key cautions, and who should avoid it.

Common side effects

Generally well toleratedOccasional mild GI upset

Who should avoid it

  • Anyone relying on it instead of evidence-based care
  • Pregnant or breastfeeding individuals (no data)

Pregnancy & breastfeeding

No reliable safety data in pregnancy or breastfeeding; avoid.

Choosing a product

What to look for on the label — and what to be skeptical of.

Look for…

Clearly labeled N,N-dimethylglycine (not 'pangamic acid' or 'B15')
Defined mg per serving
Third-party purity testing

Be skeptical of…

'Vitamin B15' or 'pangamic acid' branding
Oxygen-utilization or endurance claims
Immune-boosting or anti-cancer claims

References by claim

autism spectrum behavior

Kern et al., 2001 — PubMed (2001) link

Kato et al., 2021 — PMC (2021) link

Track DMG (Dimethylglycine) with Pilora

Set up dose reminders, check interactions, and join the community in the Pilora iPhone app.

Coming to App Store
Evidence-based·Last reviewed May 30, 2026·Evidence current as of May 30, 2026·How we grade evidence

Disclaimer: These statements have not been evaluated by the FDA. This page is educational, not a substitute for personalized medical advice. Evidence grades are AI-assisted assessments — talk to your doctor before starting any new supplement, especially if you’re pregnant, breastfeeding, on medications, or managing a chronic condition.