Dimethylresveratrol

PhytochemicalStilbenoid

What is it

Dimethylresveratrol (likely referring to pterostilbene, which is 3,5-dimethoxy-4'-hydroxystilbene, a methylated resveratrol analog) is a stilbene found in blueberries and grapevines. It is marketed as an enhanced-bioavailability alternative to resveratrol.

Evidence for 2 uses

AI-assisted evidence assessment — talk to your doctor before relying on any single supplement.

Cognitive function

Limited Evidence

Small trials suggest possible benefits for cognitive function, particularly when combined with grape polyphenols.

Blood pressure / metabolic

Limited Evidence

Some trials show modest blood pressure reduction; effects on lipids are mixed.

How it works

Pterostilbene/dimethylresveratrol has structural similarity to resveratrol but with two methoxy groups replacing hydroxyl groups, resulting in greater lipophilicity, improved oral bioavailability, and longer biological half-life. It shares many of resveratrol's activities including antioxidant, anti-inflammatory, and SIRT1-activating effects, often at lower doses. Clinical research is more limited than for resveratrol, but trials have investigated cardiovascular, cognitive, and metabolic effects.

Dosage

Pterostilbene clinical doses: 50-250 mg/day. Higher doses (>250 mg) may raise LDL cholesterol modestly per some studies.

When and how to take it

WHEN: Once or twice daily, with or without food (lipophilic - improved absorption with fat).

1 commercial form

Compare the main delivery options and what they’re best suited for.

Pterostilbene

Standard supplement form.

Higher bioavailability than resveratrol

Safety

Generally well tolerated. A trial showed mild LDL cholesterol increase at 250 mg/day. Long-term safety data are limited.

Who should be cautious

Avoid in pregnancy and lactation. Monitor lipid panel if using long-term at higher doses. Consult clinician if on cardiovascular medications.

Interactions

Theoretical interactions with anticoagulants (mild antiplatelet activity), CYP-metabolized drugs (some inhibitory activity).

Food sources

Blueberries

Amount
Trace amounts
%DV
—

Grapes

Amount
Trace amounts
%DV
—

Frequently asked questions

Is pterostilbene better than resveratrol?⌄

It has higher oral bioavailability and longer half-life. Whether this translates to better clinical outcomes is not fully established.

Does pterostilbene raise cholesterol?⌄

One trial showed modest LDL increases at 250 mg/day. Monitor lipids if using long-term at higher doses.

References

Dimethylresveratrol on NIH DSLD (US supplement label database) — NIH Dietary Supplement Label Database link

Research on Dimethylresveratrol (PubMed search) — PubMed link

Track Dimethylresveratrol with Pilora

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Evidence-based·How we grade evidence

Disclaimer: These statements have not been evaluated by the FDA. This page is educational, not a substitute for personalized medical advice. Evidence grades are AI-assisted assessments — talk to your doctor before starting any new supplement, especially if you’re pregnant, breastfeeding, on medications, or managing a chronic condition.