Dimethylphenethylamine

PhytochemicalPhenethylamine

What is it

N,N-dimethylphenethylamine (N,N-DMPEA, sometimes called "Eria jarensis extract") is a synthetic or plant-sourced trace amine sold in pre-workout and weight-loss supplements as a stimulant.

Evidence for 1 use

AI-assisted evidence assessment — talk to your doctor before relying on any single supplement.

Energy and focus

Mixed Evidence

No published human trials confirm efficacy. Effects are inferred from related compounds.

How it works

DMPEA is a beta-phenylethylamine derivative thought to act as a low-affinity trace amine-associated receptor 1 (TAAR1) ligand and a weak monoamine releaser, producing mild stimulant or mood-elevating effects. Oral bioavailability is reduced by monoamine oxidase metabolism, which may limit its potency unless combined with MAO inhibitors. Clinical human data are essentially absent; most evidence is anecdotal or from receptor binding studies.

Dosage

DSLD does not list a standardized dose. Commercial products typically supply 100-300 mg per serving as part of a stimulant blend. No safety dose ranges have been established.

When and how to take it

Usually taken before workouts. Avoid in the evening due to potential stimulant effects on sleep.

2 commercial forms

Compare the main delivery options and what they’re best suited for.

N,N-DMPEA (synthetic)

Sold as a stimulant ingredient in pre-workout blends.

Subject to first-pass MAO metabolism

Eria jarensis extract

Plant-source label often used for the same molecule.

Standardized to N,N-DMPEA content

Safety

Independent human safety data are very limited. Possible side effects based on related stimulants include increased heart rate, blood pressure, anxiety, and headache. Long-term safety is unknown.

Who should be cautious

Avoid in pregnancy, breastfeeding, cardiovascular disease, hypertension, anxiety disorders, and in anyone taking MAO inhibitors or antidepressants. Avoid before drug-tested competition; status with WADA and sport organizations varies.

Interactions

Significant theoretical risk of serotonin syndrome and hypertensive crisis when combined with MAO inhibitors, SSRIs, SNRIs, or other stimulants. Avoid combinations with prescription antidepressants.

Frequently asked questions

Is DMPEA the same as PEA?⌄

It is a methylated derivative of phenylethylamine, with different pharmacology and likely longer-lasting effects than free PEA.

Is it banned?⌄

Regulatory status varies by country and by sport governing body. Athletes should check before use.

References

Dimethylphenethylamine on NIH DSLD (US supplement label database) — NIH Dietary Supplement Label Database link

Research on Dimethylphenethylamine (PubMed search) — PubMed link

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Evidence-based·How we grade evidence

Disclaimer: These statements have not been evaluated by the FDA. This page is educational, not a substitute for personalized medical advice. Evidence grades are AI-assisted assessments — talk to your doctor before starting any new supplement, especially if you’re pregnant, breastfeeding, on medications, or managing a chronic condition.