Dihydromyricetin
Useful mainly for people seeking hangover prevention, though human evidence does not support it.
Quick decision guide
May help most
people seeking hangover prevention, though human evidence does not support it
Common dosing range
100–600 mg per occasion
When to expect effects
Hours (marketed for same-occasion use)
Watch out for
Not a license to drink more or to drive after drinking
What is it
Dihydromyricetin (DHM), also called ampelopsin, is a flavonoid extracted from the Japanese raisin tree (Hovenia dulcis) and other plants. It is widely marketed as a hangover prevention and liver-support supplement.
Is it worth it for you?
Use this as a quick fit check, not a diagnosis.
Worth considering if…
Probably skip if…
Evidence at a glance
| Goal | Effect | Best fit | Time |
|---|---|---|---|
liver support during alcohol use Mixed Evidence | Unquantified in humans | none established | Unknown |
liver support during alcohol use
- Effect
- Unquantified in humans
- Best fit
- none established
- Time
- Unknown
Evidence for 1 use
AI-assisted evidence assessment — talk to your doctor before relying on any single supplement.
liver support during alcohol use
Mechanism onlyPreclinical work suggests antioxidant activity and reduced alcohol-related hepatic oxidative stress. Human trial confirmation is lacking, and effects are limited to mechanistic and animal models rather than clinical liver outcomes.
Bottom line: Hepatoprotection is biologically plausible but unconfirmed in people.
How it works
How to take it
What to track
2 commercial forms
Compare the main delivery options and what they’re best suited for.
Dihydromyricetin (Hovenia dulcis extract)
Most common supplement source.
Standardized to DHM content.
Dihydromyricetin (vine tea, Ampelopsis grossedentata)
Used in Chinese vine tea, traditionally drunk for liver support.
Alternative source.
Safety
Know the common side effects, key cautions, and who should avoid it.
Common side effects
Who should avoid it
- pregnant or breastfeeding women
- people who would use it to drink more or drive after drinking
Pregnancy & breastfeeding
Avoid; there are no safety data and alcohol use is contraindicated.
Interactions
Theoretical interaction via GABA-A receptor binding
May alter alcohol metabolism; clinical significance unclear
Protocols featuring Dihydromyricetin
Evidence-backed routines where Dihydromyricetin plays a role.
Food sources
| Food | Amount | %DV |
|---|---|---|
| Vine tea (Ampelopsis grossedentata) | 1 cup brewed | — |
| Hovenia dulcis fruit (Japanese raisin tree) | Variable | — |
Vine tea (Ampelopsis grossedentata)
- Amount
- 1 cup brewed
- %DV
- —
Hovenia dulcis fruit (Japanese raisin tree)
- Amount
- Variable
- %DV
- —
Choosing a product
What to look for on the label — and what to be skeptical of.
Look for…
Be skeptical of…
Frequently asked questions
Does DHM actually prevent hangovers?⌄
Despite popular marketing, human clinical evidence is limited and a 2020 RCT did not show significant hangover benefit. Animal studies are more promising but do not reliably translate.
Is DHM safer than just drinking less?⌄
Drinking less or not at all is the only reliable way to avoid hangover and alcohol-related harm. DHM should not be used as license to drink more.
References by claim
Track Dihydromyricetin with Pilora
Set up dose reminders, check interactions, and join the community in the Pilora iPhone app.
Coming to App StoreDisclaimer: These statements have not been evaluated by the FDA. This page is educational, not a substitute for personalized medical advice. Evidence grades are AI-assisted assessments — talk to your doctor before starting any new supplement, especially if you’re pregnant, breastfeeding, on medications, or managing a chronic condition.