Deoxyandrographolides

PhytochemicalDiterpene lactoneBest with a meal

What is it

Deoxyandrographolides (specifically 14-deoxyandrographolide) are bioactive diterpene lactones found in Andrographis paniculata, alongside the better-known andrographolide. They contribute to the herb's pharmacological effects.

Evidence for 1 use

AI-assisted evidence assessment — talk to your doctor before relying on any single supplement.

Anti-inflammatory / antiviral (as part of andrographis)

Good Evidence

Andrographis extracts have moderate clinical evidence for acute respiratory infection symptom relief; deoxyandrographolides contribute to this effect.

How it works

14-Deoxyandrographolide shares many activities with andrographolide, including anti-inflammatory, antiviral, hepatoprotective, and immunomodulatory effects. It may have slightly different selectivity and potency profiles across various molecular targets. In standardized andrographis extracts, andrographolide is typically the dominant marker (1-6%), with deoxyandrographolides as minor co-active constituents (typically <1%).

Dosage

Not commonly dosed in isolation. Standardized andrographis extracts (containing andrographolide + deoxyandrographolides) typically dosed at 30-300 mg of andrographolides daily.

When and how to take it

Take with food to reduce GI upset. Andrographis is typically used for short courses (5-14 days) during acute respiratory illness.

1 commercial form

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Standardized andrographis extract

Standard form.

Contains andrographolide plus deoxyandrographolides

Safety

As part of andrographis extracts, generally well tolerated. Side effects can include GI upset, allergic reactions, and rare reports of liver enzyme elevations.

Who should be cautious

Avoid in pregnancy (uterotonic effects in animals). Caution in autoimmune disease. Avoid in liver disease without clinician guidance.

Interactions

Theoretical interactions with anticoagulants, immunosuppressants, and CYP-metabolized drugs.

Frequently asked questions

Is deoxyandrographolide better than andrographolide?⌄

They have overlapping activities. Standardized extracts contain both and are the practical form available.

Why are these in andrographis supplements?⌄

They are natural co-constituents contributing to the herb's anti-inflammatory and immune effects.

References

Deoxyandrographolides on NIH DSLD (US supplement label database) — NIH Dietary Supplement Label Database link

Research on Deoxyandrographolides (PubMed search) — PubMed link

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Evidence-based·How we grade evidence

Disclaimer: These statements have not been evaluated by the FDA. This page is educational, not a substitute for personalized medical advice. Evidence grades are AI-assisted assessments — talk to your doctor before starting any new supplement, especially if you’re pregnant, breastfeeding, on medications, or managing a chronic condition.