Evidence-based·Last reviewed May 31, 2026·How we grade evidence

Cod Liver Oil

Fatty-acidOmega-3Best with a meal

A traditional Scandinavian supplement pressed from cod liver — distinct from regular 'fish oil' because it contains preformed vitamin A and vitamin D alongside EPA/DHA. Real evidence for modest RA symptom relief, observational signals for childhood type 1 diabetes prevention, and a long history in rickets prevention. The defining caution is HIGH VITAMIN A — pregnant women should NOT take cod liver oil.

Quick decision guide

May help most

Adults wanting vitamin A + vitamin D + modest omega-3 in one traditional supplement; people with RA wanting an NSAID-sparing adjunct; people in low-sun-exposure regions using it as historical Scandinavian populations did.

Common dosing range

1 teaspoon (~5 mL) per day for general use — typically provides ~1000 mg total omega-3 (with ~400–600 mg combined EPA + DHA), 800–1500 mcg RAE vitamin A, and 250–1000 IU vitamin D.

When to expect effects

Weeks for vitamin D status and triglycerides; months (3–9) for RA symptom outcomes.

Watch out for

DO NOT take during pregnancy or if trying to conceive — high preformed vitamin A is teratogenic. Stacking cod liver oil with a multivitamin or separate vitamin A supplement easily exceeds the 3,000 mcg RAE/day vitamin A upper limit.

Evidence snapshot

Vitamin D status (low-sun populations)Moderate
Rheumatoid arthritis (NSAID sparing)Moderate
Childhood type 1 diabetes (observational)Emerging
Cardiovascular outcomes (extrapolated from EPA/DHA)Emerging
Rickets prevention (historical)Historical

What is it

Cod Liver Oil is a fat or oil ingredient used in dietary supplements and foods. Found on roughly 1,095 U.S. supplement labels.

Is it worth it for you?

Use this as a quick fit check, not a diagnosis.

Worth considering if

You want a single supplement that combines vitamin A, vitamin D and modest omega-3 — and you know your baseline vitamin A status is not already high
You have rheumatoid arthritis and want to try an NSAID-sparing adjunct, alongside disease-modifying therapy
You live in a low-sun region (high latitude, indoor lifestyle) and your vitamin D status is documented as low
You're following a traditional Scandinavian diet pattern and want a long-history supplement

Probably skip if

You're pregnant, trying to conceive, or breastfeeding — high preformed vitamin A is teratogenic; use a prenatal vitamin instead
You take a multivitamin or other vitamin A supplement — stacking easily exceeds the UL of 3,000 mcg RAE/day
You take a high-dose vitamin D supplement — adding cod liver oil's vitamin D may push you above the 4,000 IU/day UL
You take warfarin or other anticoagulants — discuss with prescriber; vitamin K and omega-3 both affect bleeding
You want a high-dose omega-3 effect (≥2 g EPA + DHA/day) — concentrated fish oil delivers more EPA/DHA per teaspoon without the vitamin A load
You have liver disease — high preformed retinol stresses an already-compromised liver

Evidence at a glance

Vitamin D status and rickets prevention

Strong Evidence
Effect
Each 1000 IU/day raises 25(OH)D by ~10 ng/mL in deficient adults
Best fit
Children and adults in low-sun environments; people with documented low vitamin D
Time
8–12 weeks for steady-state 25(OH)D

Rheumatoid arthritis (NSAID sparing)

Good Evidence
Effect
39% vs 10% achieved ≥30% NSAID reduction at 9 months
Best fit
Adults with rheumatoid arthritis seeking an NSAID-sparing nutritional adjunct alongside DMARDs
Time
Months (the trial measured outcomes at 9 months)

Childhood type 1 diabetes risk reduction (observational)

Limited Evidence
Effect
Maternal use OR 0.30 (95% CI 0.12–0.75); infant use OR 0.74 (95% CI 0.56–0.99)
Best fit
Families in Scandinavian populations with elevated T1D risk and low sun exposure
Time
Years (the relevant outcome is autoimmunity in childhood)

Cardiovascular (EPA + DHA extrapolation)

Limited Evidence
Effect
Modest triglyceride reduction from omega-3 content; cardiovascular event reduction unproven for cod liver oil specifically
Best fit
People wanting modest omega-3 from a traditional source
Time
Weeks for triglycerides; years for hard CV outcomes

Childhood respiratory infections

Mixed Evidence
Effect
Reduced URI clinic visits in an open trial — not placebo-controlled
Best fit
Children with documented low vitamin D status
Time
Months

Evidence for 5 uses

AI-assisted evidence assessment — talk to your doctor before relying on any single supplement.

Vitamin D status and rickets prevention

Corrects deficiency
Strong Evidence

Cod liver oil's most historically documented role: a traditional source of vitamin D for populations with limited sunlight, used since the 19th century to prevent and treat rickets. One teaspoon provides 2501000 IU vitamin D depending on product, contributing meaningfully toward the 600800 IU/day RDA. For adults living in high-latitude, low-sun environments with documented low vitamin D status, daily cod liver oil reliably raises 25(OH)D.

Effect size
Each 1000 IU/day raises 25(OH)D by ~10 ng/mL in deficient adults
Time to effect
8–12 weeks for steady-state 25(OH)D
Best fit
Children and adults in low-sun environments; people with documented low vitamin D
Less likely
Adults with adequate sun exposure and vitamin D-fortified dairy intake

Bottom line: A reliable vitamin D source — but a dedicated vitamin D3 supplement gives you the dose without the vitamin A load.

Rheumatoid arthritis (NSAID sparing)

Disease adjunct
Good Evidence

Galarraga et al. 2008 randomised 97 RA patients to cod liver oil 10 g/day (providing 2.2 g EPA + DHA) or placebo for 9 months. 39% of cod liver oil patients reduced daily NSAID requirement by30% vs 10% on placebo. Joint counts, pain scores, and quality-of-life trended favorably. Mechanism is believed to be the EPA + DHA anti-inflammatory effect, similar to high-dose fish oil RA trials. Cod liver oil's vitamin A and D add modest additional anti-inflammatory potential.

Effect size
39% vs 10% achieved ≥30% NSAID reduction at 9 months
Time to effect
Months (the trial measured outcomes at 9 months)
Best fit
Adults with rheumatoid arthritis seeking an NSAID-sparing nutritional adjunct alongside DMARDs
Less likely
RA patients in remission on biologics; people with high baseline vitamin A intake

Bottom line: A real NSAID-sparing signal for RA. Stays as ADJUNCT — never replace DMARDs.

Childhood type 1 diabetes risk reduction (observational)

Supplement benefit
Limited Evidence

Norwegian case-control studies (Stene 2000, Stene & Joner 2003) found childhood cod liver oil use in the first year of life associated with ~25% lower type 1 diabetes risk, and maternal cod liver oil intake during pregnancy associated with ~70% lower offspring type 1 diabetes risk. The signal is observational and likely reflects combined vitamin D + omega-3 effects. Confounding (cod liver oil users may differ systematically in other diet or genetic factors) cannot be ruled out without an RCT.

Effect size
Maternal use OR 0.30 (95% CI 0.12–0.75); infant use OR 0.74 (95% CI 0.56–0.99)
Time to effect
Years (the relevant outcome is autoimmunity in childhood)
Best fit
Families in Scandinavian populations with elevated T1D risk and low sun exposure
Less likely
Populations with adequate vitamin D from fortification and high background omega-3 intake

Bottom line: Interesting Scandinavian observational signal — not strong enough to recommend cod liver oil as T1D prevention, but a reason not to dismiss historical use.

Evidence is mixed

Observational data only; no confirmatory RCTs. The TEDDY and DAISY cohorts have not consistently replicated the cod-liver-oil signal in different populations.

Cardiovascular (EPA + DHA extrapolation)

Supplement benefit
Limited Evidence

Cod liver oil provides EPA + DHA, but typically less per teaspoon (400600 mg combined) than concentrated fish oil capsules (5001000+ mg per capsule). The CV evidence base for omega-3 supplements is mixed (positive for high-dose EPA in REDUCE-IT, neutral overall in VITAL and ASCEND for general prevention). Cod liver oil's EPA+DHA contribution is modest unless dosed at multiple teaspoons/day, which then pushes vitamin A intake into UL territory.

Effect size
Modest triglyceride reduction from omega-3 content; cardiovascular event reduction unproven for cod liver oil specifically
Time to effect
Weeks for triglycerides; years for hard CV outcomes
Best fit
People wanting modest omega-3 from a traditional source
Less likely
People needing high-dose EPA/DHA for hypertriglyceridemia — use prescription icosapent ethyl or high-concentration fish oil

Bottom line: Modest omega-3 dose — fine as part of a varied diet, not a substitute for high-dose EPA when you actually need it.

Childhood respiratory infections

Supplement benefit
Mixed Evidence

Linday et al. 2002 open trial in 94 young children combined cod liver oil with a multivitamin containing selenium for 47 months and reported fewer clinic visits for upper respiratory infections vs a historical comparison. Open, uncontrolled, combined interventiontoo weak to recommend cod liver oil for paediatric infection prevention on its own.

Effect size
Reduced URI clinic visits in an open trial — not placebo-controlled
Time to effect
Months
Best fit
Children with documented low vitamin D status
Less likely
Otherwise healthy children with adequate vitamin D from fortified foods

Bottom line: Preliminary data only; address vitamin D status directly if that's the goal.

How it works

Cod Liver Oil contributes fatty acids and, depending on the source, fat-soluble vitamins or other lipid-soluble compounds. In a supplement, it may be used to deliver other nutrients, serve as a carrier oil, or be sold for its own fatty acid profile. Effects on health depend on which fatty acids it contains and how much you consume.

How to take it

1. Typical dose
• 1 teaspoon (~5 mL) of liquid cod liver oil per day for general use • Capsules: 1–4 softgels per day depending on potency (read the label — vitamin A and D content vary widely) • RA adjunct dose used in Galarraga 2008: 10 g/day liquid cod liver oil (~2.2 g EPA + DHA) • ALWAYS check vitamin A content per serving and stay under 3,000 mcg RAE/day from ALL sources
2. Higher studied dose
10 g/day liquid (about 2 teaspoons) in the Galarraga RA trial — this dose can deliver 1,500–3,000 mcg RAE vitamin A/day, approaching the adult UL. Don't go higher without medical guidance.
3. Timing
Take with a meal that contains some fat — improves absorption of all the fat-soluble vitamins and omega-3. Morning or evening is fine; consistency matters more than time of day.
4. With food
With a fat-containing meal.
5. Split dosing
Single daily dose is fine at 1 teaspoon. Split if dosing 10 g/day for RA — easier on the stomach.
6. How long to try
Continuous for vitamin D maintenance if that's the goal. Evaluate RA response at 3–6 months. Re-check vitamin A and D status (and 25(OH)D, ferritin if you're stacking with prenatal multis) at least annually if using long-term.

What to track

25(OH)D level after 8–12 weeks if vitamin D status is the goal
Total daily vitamin A intake from ALL sources (label + multivitamin + liver, eggs, dairy if substantial)
Joint pain, swelling, NSAID frequency if using for RA — keep a simple log
Triglycerides if using for omega-3 effect
Symptoms of vitamin A toxicity at sustained high doses: headache, blurred vision, dry skin, hair loss, bone pain

Bottom line: Stick to ~1 teaspoon/day with a meal. Add up your TOTAL vitamin A intake (cod liver oil + multivitamin + liver / eggs / dairy) and stay under 3,000 mcg RAE/day. Pregnancy: don't.

5 commercial forms

Compare the main delivery options and what they’re best suited for.

Liquid cod liver oil (refrigerated, flavoured)

Traditional

The classic Scandinavian product. Easier to dose precisely (1 teaspoon) and to taste freshness. Lemon-flavoured versions mask the fishy taste. Use within 90 days of opening; refrigerate to slow oxidation.

All fat-soluble vitamins and omega-3 well absorbed with a fatty meal.

Cod liver oil softgels / capsules

Convenient

Sealed capsules protect against oxidation longer than liquid. Multiple softgels needed to match a teaspoon's volume; read the label for total daily vitamin A and D when taking 24 capsules.

Equivalent to liquid; per-capsule potency is lower so more capsules needed for trial doses.

Fish oil (body oil) — different supplement

No vitamin A/D

Pressed from fish body tissue, NOT liver. Contains EPA + DHA without significant vitamin A or D. The form used in most large omega-3 cardiovascular trials. Preferred when you want high EPA + DHA without the vitamin A loadand the only safe choice in pregnancy.

Higher EPA + DHA per teaspoon than cod liver oil; check label.

Fish liver oil (other species)

Variable composition

Pressed from pollock, haddock, or other cod-family livers. Composition (especially vitamin A and D) varies more than canonical cod liver oil. Sold under generic 'fish liver oil' labelling; lives at a separate nutrient page.

Vitamin A and D content highly variable by source species.

Algae-based DHA (vegetarian)

Pregnancy-safe omega-3

Provides DHA (some products also EPA) without vitamin A, vitamin D, or fish-sourcing concerns. The preferred omega-3 form for pregnancy and for vegetarians.

DHA bioavailability comparable to fish-derived; less EPA in most algae products.

Safety

Know the common side effects, key cautions, and who should avoid it.

Common side effects

fishy aftertaste or fishy belchingmild GI upsetloose stool at higher dosesrancid taste from old / poorly stored product

Serious risks

Who should avoid it

Pregnancy & breastfeeding

DO NOT use cod liver oil during pregnancy. The high preformed vitamin A content is teratogenic in early pregnancy. For pregnancy needs, use a standard prenatal vitamin (which uses beta-carotene instead of retinol), plus a separate vitamin D supplement if recommended, plus a dedicated DHA supplement (algae-based or low-vitamin-A fish oil) if your prenatal doesn't include enough. Breastfeeding: same caution — high maternal vitamin A passes into milk.

Bottom line: Watch the vitamin A. Never in pregnancy. At 1 teaspoon/day with food, otherwise generally safe for adults.

Interactions

Preformed vitamin A supplements (retinyl palmitate, retinyl acetate)Major

Cumulative vitamin A exposure can quickly exceed the 3,000 mcg RAE/day UL. Don't stack cod liver oil with a vitamin A supplement or a high-retinol multivitamin.

Isotretinoin and other oral retinoid drugsMajor

Additive vitamin A toxicity; substantially increased risk of hepatotoxicity, hyperlipidaemia, and (in pregnancy) teratogenicity. Avoid cod liver oil while on isotretinoin.

Warfarin and other vitamin-K-antagonist anticoagulantsModerate

Vitamin A and omega-3 both affect coagulation; cod liver oil intake should be kept consistent (not stop-start) and discussed with the prescriber.

High-dose vitamin D supplementsModerate

Stacking with separate vitamin D3 supplementation can exceed the 4,000 IU/day UL and risk hypercalcemia. Total daily vitamin D intake should be tracked.

Orlistat (Xenical / Alli)Moderate

Orlistat blocks fat absorption and substantially reduces uptake of fat-soluble vitamins A and D plus omega-3. Take cod liver oil at least 2 hours apart.

Bile acid sequestrants (cholestyramine, colesevelam)Moderate

Reduce absorption of fat-soluble nutrients including vitamins A and D and omega-3. Separate by several hours.

Direct oral anticoagulants (DOACs: apixaban, rivaroxaban, dabigatran)Minor

Omega-3 has mild antiplatelet effect; at typical cod liver oil doses interaction is minor but stacks with the underlying anticoagulant.

Food sources

Cod liver oil, 1 teaspoon (~4.5 g)

Amount
1 tsp (~890 mg total omega-3; ~890 mcg RAE vit A; ~450 IU vit D)
%DV
99%

Cod liver, raw

Amount
100 g (very high preformed vitamin A — avoid in pregnancy)
%DV

Fatty fish (salmon, mackerel, sardines)

Amount
3 oz (~1500–2000 mg total omega-3; modest vit D; minimal preformed vit A)
%DV

Egg yolk

Amount
1 yolk (~80 mcg RAE vit A; ~40 IU vit D)
%DV
9%

Beef liver, cooked

Amount
3 oz (~6500 mcg RAE vit A — avoid stacking with cod liver oil and avoid in pregnancy)
%DV
722%

Whole milk, fortified

Amount
1 cup (~150 mcg RAE vit A; ~115 IU vit D)
%DV
17%

Choosing a product

What to look for on the label — and what to be skeptical of.

Look for

Vitamin A (as retinol) AND vitamin D content per serving clearly listed in mcg RAE and IU — not just 'vitamins A and D'
Total EPA + DHA per serving in mg — needed to compare with fish oil
Third-party testing for heavy metals (mercury, lead, cadmium, arsenic) and PCBs — fish livers concentrate these
Antioxidants added (vitamin E / tocopherols) to prevent rancidity
Recent manufacturing date — cod liver oil oxidises over months
Refrigerated liquid form for best freshness, or dark-glass amber bottles
Source species disclosed (Atlantic cod, Gadus morhua, is the canonical product)

Be skeptical of

Use during pregnancy or 'for pregnancy support' — directly contradicts NHS/USA guidance on retinol teratogenicity
Mega-dose products (>3,000 mcg RAE vitamin A or >2,000 IU vitamin D per serving) marketed for daily lifetime use
'Same as fish oil' marketing — cod liver oil and fish (body) oil differ in vitamin A/D content and that matters
Untested cod liver oil from artisanal or non-vetted sources — fish livers accumulate contaminants
'Cures' for arthritis, asthma, diabetes, or cancer — the evidence supports modest adjunctive roles at best
'Fermented cod liver oil' marketing as superior — fermentation can degrade vitamins and omega-3, and stability claims are not well-validated

Frequently asked questions

Is Cod Liver Oil healthy?

It depends on the fatty acid profile. Cod Liver Oil can be part of a balanced diet, but it should fit within overall calorie and fat goals.

Should I take it with food?

Yes. Taking fats with a meal that contains other dietary fat supports absorption.

How should I store it?

Store as directed on the label. Many oils benefit from cool, dark storage to prevent rancidity.

References by claim

Safety

Rothman et al., 1995New England Journal of Medicine (1995) link

NIH ODS Vitamin A Health Professional Fact SheetNIH Office of Dietary Supplements (2024) link

NHS UK — Vitamins and supplements in pregnancyNHS link

Childhood type 1 diabetes risk reduction (observational)

Stene et al., 2000American Journal of Clinical Nutrition (2000) link

Stene & Joner, 2003American Journal of Clinical Nutrition (2003) link

Rheumatoid arthritis (NSAID sparing)

Galarraga et al., 2008Rheumatology (Oxford) (2008) link

Childhood respiratory infections

Linday et al., 2002Annals of Otology, Rhinology & Laryngology (2002) link

Vitamin D status and rickets prevention

NIH ODS Vitamin D Health Professional Fact SheetNIH Office of Dietary Supplements (2024) link

Other references

Brustad et al., 2020 (COPSAC2010)JAMA Pediatrics (2020) link

Cod liver oil on WikidataWikidata link

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Evidence-based·Last reviewed May 31, 2026·Evidence current as of May 31, 2026·How we grade evidence

Disclaimer: These statements have not been evaluated by the FDA. This page is educational, not a substitute for personalized medical advice. Evidence grades are AI-assisted assessments — talk to your doctor before starting any new supplement, especially if you’re pregnant, breastfeeding, on medications, or managing a chronic condition.