Citric acid transglutaminase

Enzyme

What is it

This label likely refers to a combination of citric acid and microbial transglutaminase (mTG), enzymes/agents used in food manufacturing. Microbial transglutaminase is sometimes called 'meat glue' for its protein-crosslinking ability.

Evidence for 1 use

AI-assisted evidence assessment — talk to your doctor before relying on any single supplement.

Formulation / food manufacturing

Mixed Evidence

Used as manufacturing aid; not a nutrient.

How it works

Citric acid is a common food acidulant. Transglutaminase enzymes crosslink proteins, used in food manufacturing to bind meat pieces, alter dough texture, or improve gel structures. Microbial transglutaminase is sometimes used as a digestive-support enzyme, although evidence for benefit is limited and there has been some concern about its potential role in opening tight junctions (relevant to celiac disease).

Dosage

Not a typical nutrient; used at trace levels in food and supplement manufacturing.

When and how to take it

Not applicable as a formulation aid.

1 commercial form

Compare the main delivery options and what they’re best suited for.

Microbial transglutaminase enzyme

Used in food manufacturing.

Acts in upper GI.

Safety

Generally regarded as safe in food applications. Some research has raised theoretical concerns about microbial transglutaminase exposure and intestinal permeability, particularly in genetically susceptible individuals.

Who should be cautious

People with celiac disease may want to avoid added microbial transglutaminase due to theoretical concerns about gluten interaction.

Interactions

No significant interactions documented in supplement context.

Frequently asked questions

Is transglutaminase safe?⌄

Generally yes in food amounts; some theoretical concerns in celiac disease.

Why are these in my supplement?⌄

As manufacturing aids; citric acid is also an acidulant and preservative.

References

Citric acid transglutaminase on NIH DSLD (US supplement label database) — NIH Dietary Supplement Label Database link

Research on Citric acid transglutaminase (PubMed search) — PubMed link

Track Citric acid transglutaminase with Pilora

Set up dose reminders, check interactions, and join the community in the Pilora iPhone app.

Coming to App Store
Evidence-based·How we grade evidence

Disclaimer: These statements have not been evaluated by the FDA. This page is educational, not a substitute for personalized medical advice. Evidence grades are AI-assisted assessments — talk to your doctor before starting any new supplement, especially if you’re pregnant, breastfeeding, on medications, or managing a chronic condition.