Evidence-based·Last reviewed May 30, 2026·How we grade evidence

Chanca Piedra

BotanicalBest taken away from food

Useful mainly for people prone to calcium oxalate kidney stones looking for an adjunct.

Quick decision guide

May help most

people prone to calcium oxalate kidney stones looking for an adjunct

Common dosing range

400–1500 mg/day standardized extract

When to expect effects

Weeks to months

Watch out for

may lower blood pressure and blood sugar; not a substitute for medical stone management

What is it

Chanca piedra (Phyllanthus niruri, also bhumyamalaki in Ayurveda) is a small tropical plant used traditionally for kidney stones, liver complaints, and hepatitis. The name means 'stone breaker' in Spanish.

Is it worth it for you?

Use this as a quick fit check, not a diagnosis.

Worth considering if

you have recurrent calcium oxalate stones and want a low-risk adjunct
your clinician is managing the underlying cause and you want to try it alongside
you tolerate it and track stone recurrence over months

Probably skip if

you expect it to dissolve or pass an existing obstructing stone reliably
you have chronic hepatitis B and are looking for a proven treatment
you are on blood-pressure or diabetes medication and cannot monitor closely

Evidence at a glance

calcium oxalate kidney stones

Limited Evidence
Effect
Uncertain; modest at best
Best fit
people with recurrent calcium oxalate stones
Time
Weeks to months

chronic hepatitis B

Mixed Evidence
Effect
Inconsistent
Best fit
not established
Time
Weeks to months

Evidence for 2 uses

AI-assisted evidence assessment — talk to your doctor before relying on any single supplement.

calcium oxalate kidney stones

Supplement benefit
Limited Evidence

In vitro work shows Phyllanthus extracts inhibit calcium oxalate crystal formation and aggregation, and a few small human trials suggest possible benefit for stone passage or reduced crystalluria. Trials are small, heterogeneous, and not consistently positive, and larger high-quality studies are lacking.

Effect size
Uncertain; modest at best
Time to effect
Weeks to months
Best fit
people with recurrent calcium oxalate stones
Less likely
people with non-oxalate stones or acute obstruction

Bottom line: A plausible low-risk adjunct for recurrent oxalate stones, but the human evidence is thin and inconsistent.

Evidence is mixed

Some small trials report fewer or smaller stones while others show no significant difference versus control. Methodology and extract standardization vary widely.

chronic hepatitis B

Biomarker support
Mixed Evidence

Some studies report antiviral activity against hepatitis B surface antigen and modest changes in liver markers, but trial results conflict and a Cochrane review found no convincing evidence that Phyllanthus clears the virus or improves clinical outcomes. Changes seen are biomarker-level and not reliably reproduced.

Effect size
Inconsistent
Time to effect
Weeks to months
Best fit
not established

Bottom line: Evidence does not support Phyllanthus as a treatment for hepatitis B.

Evidence is mixed

Early small trials suggested HBsAg clearance, but pooled and higher-quality data do not confirm a benefit on viral or clinical endpoints.

How it works

Phyllanthus extracts contain lignans (phyllanthin, hypophyllanthin), flavonoids, and tannins that have shown in vitro inhibition of calcium oxalate crystallization, mild diuretic effects, and antiviral activity against hepatitis B surface antigen in some studies. Clinical evidence in humans is mixed: a few small trials show possible benefit for stone passage and modest changes in liver markers, but larger high-quality trials are limited and results inconsistent.

How to take it

1. Typical dose
400–1500 mg/day of standardized extract, or 1–3 g/day dried herb
2. Timing
between meals; trials vary in schedule
3. With food
typically on an empty stomach
4. How long to try
trial for 1–3 months and reassess stone recurrence

What to track

stone passage or recurrence
blood pressure
blood glucose if diabetic
GI tolerance

2 commercial forms

Compare the main delivery options and what they’re best suited for.

Standardized extract

Capsules or tablets, typical of clinical trials.

Often standardized to phyllanthin content.

Whole-herb powder

Used in teas or capsules.

Less concentrated; traditional preparation.

Safety

Know the common side effects, key cautions, and who should avoid it.

Common side effects

mild GI upsetfatiguedizziness

Who should avoid it

  • pregnant or breastfeeding women
  • people on antihypertensive or antidiabetic drugs without monitoring
  • those within 2 weeks of surgery

Pregnancy & breastfeeding

Avoid in pregnancy and lactation due to lack of safety data and traditional use as an emmenagogue.

Interactions

antihypertensive drugsModerate

additive blood-pressure lowering

antidiabetic drugsModerate

additive blood-sugar lowering

lithiumModerate

diuretic effect may alter lithium levels

diureticsMinor

additive diuretic effect

Choosing a product

What to look for on the label — and what to be skeptical of.

Look for

named species (Phyllanthus niruri or amarus)
standardized extract with stated ratio or marker content
third-party tested

Be skeptical of

dissolves kidney stones
cures hepatitis
detoxes the liver

Frequently asked questions

Does chanca piedra actually dissolve kidney stones?

It does not dissolve existing stones in a clinically meaningful sense. Some small studies suggest it may help with passage or reduce recurrence, but evidence is limited.

Is it safe to take with diabetes medication?

Use with caution. Chanca piedra may lower blood sugar; monitor closely and discuss with your clinician.

References by claim

calcium oxalate kidney stones

Nishiura et al., 2004PubMed (2004) link

Micali et al., 2006PubMed (2006) link

chronic hepatitis B

Liu et al., 2001PubMed (2001) link

Xia et al., 2011PubMed (2011) link

Track Chanca Piedra with Pilora

Set up dose reminders, check interactions, and join the community in the Pilora iPhone app.

Coming to App Store
Evidence-based·Last reviewed May 30, 2026·Evidence current as of May 30, 2026·How we grade evidence

Disclaimer: These statements have not been evaluated by the FDA. This page is educational, not a substitute for personalized medical advice. Evidence grades are AI-assisted assessments — talk to your doctor before starting any new supplement, especially if you’re pregnant, breastfeeding, on medications, or managing a chronic condition.