Capsiate

PhytochemicalCapsinoidBest with a meal

What is it

Capsiate is a non-pungent analog of capsaicin found in CH-19 Sweet, a sweet (non-spicy) variety of Capsicum annuum; it is sold as a thermogenic supplement.

Evidence for 1 use

AI-assisted evidence assessment — talk to your doctor before relying on any single supplement.

Energy expenditure and fat oxidation

Good Evidence

Small RCTs show modest increases in resting energy expenditure and fat oxidation; clinically meaningful weight loss is unclear.

How it works

Capsiate activates TRPV1 receptors in the gut and produces mild sympathetic nervous system activation without the oral burn of capsaicin. Studies show small increases in resting energy expenditure and brown adipose tissue activity in humans. Unlike capsaicin, capsiate is hydrolyzed rapidly in the gut and so does not cause the burning sensation associated with chili peppers.

Dosage

No RDA. Thermogenesis trials use 6-9 mg of capsiate or capsinoids per day.

When and how to take it

WHEN: With meals. HOW: Take 6-9 mg per day, often split before meals.

1 commercial form

Compare the main delivery options and what they’re best suited for.

Capsimax (capsinoid blend)

The branded ingredient used in most thermogenic supplements.

Beadlet technology releases in small intestine.

Safety

Generally well tolerated. Mild GI symptoms are occasional. No serious adverse events reported at typical doses.

Who should be cautious

Limited pregnancy data. Caution in active peptic ulcer disease, though risk appears lower than with capsaicin.

Interactions

No significant interactions reported.

Food sources

Sweet pepper varieties (CH-19)

Amount
Variable
%DV
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Frequently asked questions

Does capsiate make food spicy?⌄

No. It activates the same receptor systemically but is too rapidly hydrolyzed in the mouth to cause burning.

References

Capsiate on Wikidata — Wikidata link

Capsiate on NIH DSLD (US supplement label database) — NIH Dietary Supplement Label Database link

Research on Capsiate (PubMed search) — PubMed link

Track Capsiate with Pilora

Set up dose reminders, check interactions, and join the community in the Pilora iPhone app.

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Evidence-based·How we grade evidence

Disclaimer: These statements have not been evaluated by the FDA. This page is educational, not a substitute for personalized medical advice. Evidence grades are AI-assisted assessments — talk to your doctor before starting any new supplement, especially if you’re pregnant, breastfeeding, on medications, or managing a chronic condition.