Cannabidivarin

PhytochemicalCannabinoidBest with a meal

What is it

Cannabidivarin (CBDV) is a non-intoxicating cannabinoid found in some cannabis varieties. It is structurally related to CBD (cannabidiol) but with a propyl side chain instead of a pentyl chain.

How it works

CBDV interacts with multiple receptor systems including TRPV1, TRPV2, and TRPA1 channels, and modulates the endocannabinoid system. Unlike THC, it does not bind CB1 receptors meaningfully and is not intoxicating. Research is in earlier stages than for CBD. Investigational uses focus on epilepsy, autism spectrum disorder, and various neurodevelopmental conditions. Human clinical trials are ongoing and currently limited in scope.

Dosage

Investigational doses in clinical trials have ranged from 200 mg to 800 mg per day in oral solution. There is no established consumer dose.

When and how to take it

Investigational use has been once or twice daily, often with food to support absorption.

1 commercial form

Compare the main delivery options and what they’re best suited for.

CBDV oral solution

Used in clinical trials for epilepsy and autism research.

Lipid-soluble; absorption improved with fat.

Safety

In trials, CBDV has shown a generally favorable safety profile, similar to CBD. Reported effects include mild gastrointestinal symptoms and somnolence. Long-term safety data is limited.

Who should be cautious

Pregnant and breastfeeding people should avoid in the absence of safety data. People taking multiple medications, particularly antiepileptics, should consult a clinician.

Interactions

Like CBD, CBDV may inhibit liver enzymes (CYP3A4, CYP2C19) and theoretically affect metabolism of many medications. Combine cautiously with prescription drugs.

Frequently asked questions

Is CBDV the same as CBD?⌄

They are related but distinct cannabinoids. CBDV has a shorter side chain and a slightly different pharmacological profile.

Will CBDV get me high?⌄

No. CBDV does not meaningfully activate CB1 receptors and is not intoxicating.

References

Cannabidivarin on Wikidata — Wikidata link

Cannabidivarin (PubChem CID 91158) — PubChem link

Cannabidivarin on NIH DSLD (US supplement label database) — NIH Dietary Supplement Label Database link

Research on Cannabidivarin (PubMed search) — PubMed link

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Evidence-based·How we grade evidence

Disclaimer: These statements have not been evaluated by the FDA. This page is educational, not a substitute for personalized medical advice. Evidence grades are AI-assisted assessments — talk to your doctor before starting any new supplement, especially if you’re pregnant, breastfeeding, on medications, or managing a chronic condition.