Cannabichromene

PhytochemicalCannabinoid

What is it

Cannabichromene (CBC) is a non-psychoactive minor cannabinoid found in cannabis and hemp. It is one of the four most abundant cannabinoids and is increasingly available in hemp-derived 'full-spectrum' and 'broad-spectrum' products.

Evidence for 2 uses

AI-assisted evidence assessment — talk to your doctor before relying on any single supplement.

Anti-inflammatory / analgesic

Mixed Evidence

Preclinical evidence supports these effects, but human clinical evidence specifically for CBC is limited.

Mood support (depression-like effects)

Mixed Evidence

Preclinical antidepressant-like effects; no human trials.

How it works

CBC has unique pharmacology compared to CBD and THC. It is a TRPV1 (vanilloid receptor) agonist, modulates the endocannabinoid system without strong CB1/CB2 receptor activity, and may inhibit anandamide reuptake. Preclinical studies suggest anti-inflammatory, analgesic, antidepressant-like, and neurogenic effects. Clinical human evidence specifically for CBC is very limited; most use is as part of full-spectrum hemp products where it contributes to the 'entourage effect' alongside other cannabinoids.

Dosage

No established dose. Products vary widely; common adult doses are 10-50 mg per serving.

When and how to take it

WHEN: As needed or 1-2 times daily. HOW: Sublingual oils have faster onset than capsules.

2 commercial forms

Compare the main delivery options and what they’re best suited for.

CBC isolate / extract

Sold as standalone or 'minor cannabinoid' products.

Lipophilic - take with fat

Full-spectrum hemp (contains CBC)

Most common natural source.

Combined with other cannabinoids

Safety

Generally well tolerated in available reports. Long-term safety data are limited. Full-spectrum products must contain <0.3% THC for federal US compliance.

Who should be cautious

Avoid in pregnancy and lactation. People on multiple medications should consult clinician/pharmacist. Quality varies; choose third-party tested products.

Interactions

Likely shares CYP inhibition with other cannabinoids - theoretical interactions with many medications including anticoagulants, antiepileptics, statins, immunosuppressants.

Frequently asked questions

Will CBC get me high?⌄

No. CBC is non-psychoactive.

Is CBC legal?⌄

Hemp-derived CBC products with <0.3% THC are federally legal in the US, but state laws vary.

References

Cannabichromene on Wikidata — Wikidata link

Cannabichromene (ChEBI:3357) — ChEBI link

Cannabichromene (PubChem CID 30219) — PubChem link

Cannabichromene on NIH DSLD (US supplement label database) — NIH Dietary Supplement Label Database link

Research on Cannabichromene (PubMed search) — PubMed link

Track Cannabichromene with Pilora

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Evidence-based·How we grade evidence

Disclaimer: These statements have not been evaluated by the FDA. This page is educational, not a substitute for personalized medical advice. Evidence grades are AI-assisted assessments — talk to your doctor before starting any new supplement, especially if you’re pregnant, breastfeeding, on medications, or managing a chronic condition.