Beta-glucogallin

PhytochemicalPolyphenolBest with a meal

What is it

Beta-glucogallin (1-O-galloyl-beta-D-glucose) is a polyphenol found in amla (Indian gooseberry, Phyllanthus emblica), Terminalia chebula, and a few other plants. It is studied as one of the active components of amla's reputed eye health and antioxidant effects.

Evidence for 1 use

AI-assisted evidence assessment — talk to your doctor before relying on any single supplement.

Eye health and diabetic complications (mechanism-based)

Mixed Evidence

Aldose reductase inhibition by beta-glucogallin is established in laboratory and animal studies. Direct human clinical evidence is limited; most data are from whole-amla extract trials.

How it works

Beta-glucogallin inhibits aldose reductase, an enzyme involved in the polyol pathway that contributes to diabetic complications such as cataracts and neuropathy. Inhibiting aldose reductase reduces sorbitol accumulation in tissues exposed to high glucose. Laboratory and animal studies support this mechanism. Human clinical evidence specifically for isolated beta-glucogallin is limited; most evidence comes from amla extracts.

Dosage

There is no established standalone dose. Amla extracts standardized for beta-glucogallin (such as Saberry) are typically used at 250-500 mg/day.

When and how to take it

Typically taken with meals. Follow the source product (often amla extract) label.

1 commercial form

Compare the main delivery options and what they’re best suited for.

Amla extract (standardized for beta-glucogallin)

Common form in eye-health supplements.

Polyphenol absorbed and metabolized

Safety

As a component of widely used amla, beta-glucogallin has a long history of dietary exposure. Concentrated extracts are generally well-tolerated; some people experience mild GI upset.

Who should be cautious

Pregnancy and breastfeeding: dietary amla intake is generally safe; concentrated extracts have less data. People with diabetes should monitor blood glucose.

Interactions

Polyphenol content may modestly affect drug metabolism in laboratory studies. No well-established clinical interactions at typical doses.

Food sources

Amla (Indian gooseberry) fruit

Amount
1 fruit (~12 g)
%DV
—

Frequently asked questions

Is beta-glucogallin the same as amla?⌄

It is one of the active polyphenols in amla. Amla also contains vitamin C and many other polyphenols.

Does it help with eye health?⌄

Mechanism-based evidence suggests it may reduce sorbitol accumulation in the lens. Direct human clinical evidence is limited.

References

Beta-glucogallin on Wikidata — Wikidata link

Beta-glucogallin (ChEBI:15834) — ChEBI link

Beta-glucogallin (PubChem CID 124021) — PubChem link

Beta-glucogallin on NIH DSLD (US supplement label database) — NIH Dietary Supplement Label Database link

Research on Beta-glucogallin (PubMed search) — PubMed link

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Evidence-based·How we grade evidence

Disclaimer: These statements have not been evaluated by the FDA. This page is educational, not a substitute for personalized medical advice. Evidence grades are AI-assisted assessments — talk to your doctor before starting any new supplement, especially if you’re pregnant, breastfeeding, on medications, or managing a chronic condition.