Anserine

ProteinBest with a meal

What is it

Anserine is a dipeptide composed of beta-alanine and 1-methylhistidine. It is found in skeletal muscle of birds and fish, and is structurally related to carnosine. It is sometimes included in performance and brain-health supplements.

Evidence for 1 use

AI-assisted evidence assessment — talk to your doctor before relying on any single supplement.

Cognitive function in older adults

Limited Evidence

Small Japanese trials of chicken anserine/carnosine blends suggest modest cognitive benefits in older adults. Independent replication is limited.

How it works

Anserine acts as a buffer against acid buildup in muscle during exercise, similar to carnosine. It also has antioxidant activity, helping neutralize reactive oxygen species and protect proteins from glycation. Unlike carnosine, anserine is more resistant to breakdown by the enzyme carnosinase in human blood, which may translate to longer plasma persistence. Some Japanese research has examined chicken-derived anserine and carnosine blends for cognitive support in older adults.

Dosage

Research doses for anserine-containing chicken-extract blends range from 1 to 2 g per day. Pure anserine supplements are less common; products often combine it with carnosine.

When and how to take it

Anserine can be taken with meals. Athletic users often take it before or after training, mirroring beta-alanine and carnosine protocols.

1 commercial form

Compare the main delivery options and what they’re best suited for.

Chicken anserine/carnosine extract

Most supplements use a chicken-derived extract combining anserine and carnosine.

Absorbed in small intestine; anserine more carnosinase-resistant than carnosine.

Safety

Generally well tolerated in published studies. Mild gastrointestinal symptoms are the most common report. Animal-source anserine carries the usual considerations for poultry-derived ingredients.

Who should be cautious

Vegetarians and vegans may prefer alternatives because anserine in supplements is typically derived from chicken or fish. Pregnant and breastfeeding people should consult a clinician.

Interactions

No significant medication interactions reported.

Food sources

Chicken breast

Amount
3 oz
%DV
—

Tuna

Amount
3 oz
%DV
—

Frequently asked questions

What is the difference between anserine and carnosine?⌄

Anserine has an extra methyl group on the histidine ring, which makes it more resistant to breakdown by carnosinase in human blood.

Is anserine vegetarian?⌄

No. Anserine in supplements is typically extracted from chicken or fish muscle.

References

Anserine on Wikidata — Wikidata link

Anserine (ChEBI:18323) — ChEBI link

Anserine (PubChem CID 112072) — PubChem link

Anserine on NIH DSLD (US supplement label database) — NIH Dietary Supplement Label Database link

Research on Anserine (PubMed search) — PubMed link

Track Anserine with Pilora

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Evidence-based·How we grade evidence

Disclaimer: These statements have not been evaluated by the FDA. This page is educational, not a substitute for personalized medical advice. Evidence grades are AI-assisted assessments — talk to your doctor before starting any new supplement, especially if you’re pregnant, breastfeeding, on medications, or managing a chronic condition.