Amyloban

BotanicalLion's mane compoundBest with a meal

What is it

Amyloban is a proprietary mushroom extract from Hericium erinaceus (lion's mane mushroom), standardized to amyloban (a fraction of the mushroom thought to contain hericenones and erinacines).

Evidence for 1 use

AI-assisted evidence assessment — talk to your doctor before relying on any single supplement.

Cognitive support in mild cognitive impairment

Limited Evidence

Small trials of whole lion's mane extracts suggest modest cognitive benefits. Specific evidence for the Amyloban fraction is limited.

How it works

Lion's mane mushroom contains hericenones from the fruiting body and erinacines from the mycelium. Both have been shown in cell and animal studies to stimulate nerve growth factor (NGF) production, which may support neuronal health and cognition. Amyloban as a standardized fraction is marketed for cognitive support, mood, and dementia care. Human trial data exist for whole lion's mane extracts in mild cognitive impairment and mood, with modest positive findings. Evidence specific to the proprietary Amyloban fraction is more limited.

Dosage

DSLD does not list a single standardized dose. The Amyloban 3399 product is typically dosed at 1-2 capsules (96 mg per capsule) two or three times daily. Lion's mane extract doses overall range from 500-3000 mg per day.

When and how to take it

Often taken in two or three divided doses with food.

1 commercial form

Compare the main delivery options and what they’re best suited for.

Amyloban 3399 (standardized Hericium extract)

Proprietary lion's mane extract used in cognitive products.

Standardized to amyloban fraction

Safety

Lion's mane mushroom is generally well tolerated. Mild GI upset, itching, and rare allergic reactions have been reported. Long-term safety data are limited but encouraging at studied doses.

Who should be cautious

Avoid in mushroom allergy. Use cautiously with anticoagulants and before surgery. Pregnant and breastfeeding people should consult a clinician.

Interactions

Possible mild antiplatelet activity. No major drug interactions documented.

Food sources

Lion's mane mushroom

Amount
Cooked as food
%DV
—

Frequently asked questions

Is Amyloban the same as lion's mane?⌄

Amyloban is a proprietary standardized fraction of lion's mane mushroom, marketed for cognitive support.

Does it work for dementia?⌄

Small trials are encouraging but evidence is preliminary. It should not replace medical evaluation and treatment of dementia.

References

Amyloban on NIH DSLD (US supplement label database) — NIH Dietary Supplement Label Database link

Research on Amyloban (PubMed search) — PubMed link

Track Amyloban with Pilora

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Evidence-based·How we grade evidence

Disclaimer: These statements have not been evaluated by the FDA. This page is educational, not a substitute for personalized medical advice. Evidence grades are AI-assisted assessments — talk to your doctor before starting any new supplement, especially if you’re pregnant, breastfeeding, on medications, or managing a chronic condition.