Aminoglycine

Amino-acidGlycine derivativeBest before bed

What is it

Aminoglycine generally refers to glycine derivatives or chelated amino acid forms used in supplement labels. The term is non-standard and can describe glycine itself or amino-acid glycine chelates of minerals.

Evidence for 1 use

AI-assisted evidence assessment — talk to your doctor before relying on any single supplement.

Sleep quality (glycine)

Good Evidence

Small trials suggest 3 g of glycine before bed may improve subjective sleep quality and reduce daytime fatigue. Effects are modest.

How it works

If the product refers to glycine, it serves as a non-essential amino acid involved in collagen synthesis, neurotransmission (inhibitory at glycine receptors), bile acid conjugation, and as a precursor to glutathione. If the term refers to mineral glycinates (like magnesium glycinate or zinc glycinate), glycine functions as a chelator that may improve mineral absorption and tolerability. Because the term is ambiguous, the mechanism depends entirely on what the manufacturer specifies.

Dosage

No established RDA for aminoglycine specifically. Glycine itself has no UL; typical supplement doses range from 1-15 g daily depending on purpose (collagen support, sleep, glucose). Mineral glycinate doses depend on the mineral.

When and how to take it

WHEN: For sleep applications, 1-3 g of glycine 30-60 minutes before bed. For collagen support or muscle, divided throughout the day. HOW: Mix powder in water or take capsules with water.

2 commercial forms

Compare the main delivery options and what they’re best suited for.

Glycine (free amino acid)

The amino acid itself, used in powder or capsule form.

Well-absorbed orally; sweet-tasting.

Mineral glycinate (chelate)

Glycine chelated with minerals like magnesium, zinc, or iron.

Often better tolerated and absorbed than mineral oxides or sulfates.

Safety

Glycine is generally safe at typical supplement doses. Mild side effects include nausea, soft stools, and drowsiness at higher doses. Glycine chelates of minerals can cause GI symptoms.

Who should be cautious

People with kidney disease should discuss high-dose glycine use with a clinician. Limited data in pregnancy at supplement doses. Clarify with the manufacturer what 'aminoglycine' refers to.

Interactions

Glycine may modestly enhance the effects of sedatives and clozapine. Mineral glycinate forms may affect absorption of certain antibiotics and bisphosphonates; separate timing.

Food sources

Bone broth, gelatin, collagen-rich foods

Amount
Variable
%DV
—

Frequently asked questions

Is aminoglycine just glycine?⌄

Often yes, but the label may also refer to amino-acid mineral chelates. Check with the manufacturer for clarity.

References

Aminoglycine on NIH DSLD (US supplement label database) — NIH Dietary Supplement Label Database link

Research on Aminoglycine (PubMed search) — PubMed link

Track Aminoglycine with Pilora

Set up dose reminders, check interactions, and join the community in the Pilora iPhone app.

Coming to App Store
Evidence-based·How we grade evidence

Disclaimer: These statements have not been evaluated by the FDA. This page is educational, not a substitute for personalized medical advice. Evidence grades are AI-assisted assessments — talk to your doctor before starting any new supplement, especially if you’re pregnant, breastfeeding, on medications, or managing a chronic condition.